Publication
Patient perspectives in the benefit-risk evaluation of drugs
de Vries, S., 2015, [Groningen]: University of Groningen. 249 p.Research output: Thesis › Thesis fully internal (DIV)

Documents
- Title and contents
Final publisher's version, 550 KB, PDF document
- Chapter 1
Final publisher's version, 666 KB, PDF document
- Chapter 2
Final publisher's version, 451 KB, PDF document
- Chapter 3
Final publisher's version, 568 KB, PDF document
- Chapter 4
Final publisher's version, 631 KB, PDF document
- Chapter 5
Final publisher's version, 2.25 MB, PDF document
- Chapter 6
Final publisher's version, 374 KB, PDF document
- Summaries
Final publisher's version, 551 KB, PDF document
- Appendices
Final publisher's version, 883 KB, PDF document
- Complete dissertation
Final publisher's version, 4.56 MB, PDF document
- Propositions
Final publisher's version, 289 KB, PDF document
DOI
The patient perspective in the process of drug evaluation and drug use is high on the agenda, which is demonstrated by an increased use of patient-reported outcome instruments to evaluate drugs and a shift towards patient-centred care in clinical practice. This thesis contains studies focusing on 1) the development and validation of a patient-reported outcome instrument to assess adverse drug events (ADEs), and 2) the role of patient characteristics and preferences on treatment decisions in clinical practice. The first part presents the development of a generic questionnaire to assess ADEs from the patient perspective. Although this questionnaire showed sufficient content and concurrent validity to detect ADEs at a general level, it was not sensitive enough to detect all ADEs perceived by patients. Suggestions are provided to improve the questionnaire for future use. In the second part, insight in decisions to start or intensify treatment with special attention for different patient age groups is provided. It was found that age influenced prescribing behaviour as well as the patient's willingness to add a drug. For all patients, preventing death and ADEs were important considerations when choosing an additional drug. The influence of beliefs about benefits and risks on patients’ drug adherence, however, differed among types of drugs. These findings can be used to improve the assessment of ADEs from the patient perspective, to incorporate the patient perspective in treatment decisions and to develop better tailored interventions for improving drug adherence.
Translated title of the contribution | Patiëntenperspectief in de benefit-risk evaluatie van medicijnen |
---|---|
Original language | English |
Qualification | Doctor of Philosophy |
Awarding Institution | |
Supervisors/Advisors |
|
Award date | 22-Apr-2015 |
Place of Publication | [Groningen] |
Publisher | |
Print ISBNs | 978-90-367-7683-7 |
Electronic ISBNs | 978-90-367-7682-0 |
Publication status | Published - 2015 |
Download statistics
No data available
ID: 17596083