Publication

Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?

Heeringa, P. & Tervaert, JWC., May-2004, In : Kidney International. 65, 5, p. 1564-1567 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Heeringa, P., & Tervaert, JWC. (2004). Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic? Kidney International, 65(5), 1564-1567.

Author

Heeringa, P ; Tervaert, JWC. / Pathophysiology of ANCA-associated vasculitides : are ANCA really pathogenic?. In: Kidney International. 2004 ; Vol. 65, No. 5. pp. 1564-1567.

Harvard

Heeringa, P & Tervaert, JWC 2004, 'Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?', Kidney International, vol. 65, no. 5, pp. 1564-1567.

Standard

Pathophysiology of ANCA-associated vasculitides : are ANCA really pathogenic? / Heeringa, P; Tervaert, JWC.

In: Kidney International, Vol. 65, No. 5, 05.2004, p. 1564-1567.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Heeringa P, Tervaert JWC. Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic? Kidney International. 2004 May;65(5):1564-1567.


BibTeX

@article{1836f06817d748d58fdc14e82c394936,
title = "Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?",
abstract = "The strong association of antineutrophil cytoplasmic autoantibodies (ANCA) with certain forms of small vessel vasculitis suggests a pathogenic role of these autoantibodies in the disease process. In vitro, ANCA can activate neutrophils and monocytes to produce reactive oxygen intermediates, to release lysosomal enzymes, and to secrete proinflammatory cytokines. More recently, it was demonstrated that antimyeloperoxidase ANCA can induce systemic vasculitis and glomerulonephritis in mice. Taken together, these data provide convincing evidence that ANCA are indeed pathogenic.",
keywords = "ANCA, vasculitis, microscopic polyangiitis, ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, HUMAN NEUTROPHILS, SYSTEMIC VASCULITIS, ACTIVATED NEUTROPHILS, ENDOTHELIAL-CELLS, RESPIRATORY BURST, AUTOANTIBODIES, MYELOPEROXIDASE, GLOMERULONEPHRITIS, MODEL",
author = "P Heeringa and JWC Tervaert",
year = "2004",
month = "5",
language = "English",
volume = "65",
pages = "1564--1567",
journal = "Kidney International",
issn = "0085-2538",
publisher = "ELSEVIER SCIENCE INC",
number = "5",

}

RIS

TY - JOUR

T1 - Pathophysiology of ANCA-associated vasculitides

T2 - are ANCA really pathogenic?

AU - Heeringa, P

AU - Tervaert, JWC

PY - 2004/5

Y1 - 2004/5

N2 - The strong association of antineutrophil cytoplasmic autoantibodies (ANCA) with certain forms of small vessel vasculitis suggests a pathogenic role of these autoantibodies in the disease process. In vitro, ANCA can activate neutrophils and monocytes to produce reactive oxygen intermediates, to release lysosomal enzymes, and to secrete proinflammatory cytokines. More recently, it was demonstrated that antimyeloperoxidase ANCA can induce systemic vasculitis and glomerulonephritis in mice. Taken together, these data provide convincing evidence that ANCA are indeed pathogenic.

AB - The strong association of antineutrophil cytoplasmic autoantibodies (ANCA) with certain forms of small vessel vasculitis suggests a pathogenic role of these autoantibodies in the disease process. In vitro, ANCA can activate neutrophils and monocytes to produce reactive oxygen intermediates, to release lysosomal enzymes, and to secrete proinflammatory cytokines. More recently, it was demonstrated that antimyeloperoxidase ANCA can induce systemic vasculitis and glomerulonephritis in mice. Taken together, these data provide convincing evidence that ANCA are indeed pathogenic.

KW - ANCA

KW - vasculitis

KW - microscopic polyangiitis

KW - ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES

KW - HUMAN NEUTROPHILS

KW - SYSTEMIC VASCULITIS

KW - ACTIVATED NEUTROPHILS

KW - ENDOTHELIAL-CELLS

KW - RESPIRATORY BURST

KW - AUTOANTIBODIES

KW - MYELOPEROXIDASE

KW - GLOMERULONEPHRITIS

KW - MODEL

M3 - Article

VL - 65

SP - 1564

EP - 1567

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 5

ER -

ID: 13909246