Publication

Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?

Heeringa, P. & Tervaert, JWC., May-2004, In : Kidney International. 65, 5, p. 1564-1567 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

The strong association of antineutrophil cytoplasmic autoantibodies (ANCA) with certain forms of small vessel vasculitis suggests a pathogenic role of these autoantibodies in the disease process. In vitro, ANCA can activate neutrophils and monocytes to produce reactive oxygen intermediates, to release lysosomal enzymes, and to secrete proinflammatory cytokines. More recently, it was demonstrated that antimyeloperoxidase ANCA can induce systemic vasculitis and glomerulonephritis in mice. Taken together, these data provide convincing evidence that ANCA are indeed pathogenic.

Original languageEnglish
Pages (from-to)1564-1567
Number of pages4
JournalKidney International
Volume65
Issue number5
Publication statusPublished - May-2004
EventSymposium on Immunology in Renal Disease - Berlin, Germany
Duration: 2-Jun-20035-Jun-2003

Event

Symposium on Immunology in Renal Disease

02/06/200305/06/2003

Germany

Event: Conference

    Keywords

  • ANCA, vasculitis, microscopic polyangiitis, ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, HUMAN NEUTROPHILS, SYSTEMIC VASCULITIS, ACTIVATED NEUTROPHILS, ENDOTHELIAL-CELLS, RESPIRATORY BURST, AUTOANTIBODIES, MYELOPEROXIDASE, GLOMERULONEPHRITIS, MODEL

View graph of relations

ID: 13909246