Publication

Pathogenesis of vasculitis

Kallenberg, C. & Heeringa, P., 1998, In : Lupus. 7, 4, p. 280-284 5 p.

Research output: Contribution to journalReview articleAcademicpeer-review

This review discusses current thoughts on the pathogenesis of vasculitis. Secondary vasculitides, frequently associated with infections or systemic autoimmune diseases, are, in most cases, characterized by immune deposits in the vessel wall, which probably underlies the development of lesions. In the primary vasculitides, immune deposits are generally absent. A group of primary vasculitides is, however, strongly associated with anti-neutrophil cytoplasmic autoantibodies (ANCA). Various in vitro and in vivo experimental data suggest that those ANCA are involved in the pathogenesis of lesions in the associated disorders.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalLupus
Volume7
Issue number4
Publication statusPublished - 1998

    Keywords

  • systemic vasculitis, anti-neutrophil cytoplasmic antibodies, Wegener's granulomatosis, pathophysiology, HUMAN ENDOTHELIAL-CELLS, ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES, WEGENERS-GRANULOMATOSIS, SYSTEMIC VASCULITIS, ANTIMYELOPEROXIDASE ANTIBODIES, EXPRESS PROTEINASE-3, NEUTROPHILS, GLOMERULONEPHRITIS, MYELOPEROXIDASE, ANCA

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ID: 2010810