Publication

Pathogenesis of cutaneous lupus erythematosus

Kuhn, A. & Bijl, M., 2008, In : Lupus. 17, 5, p. 389-393 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • A. Kuhn
  • M. Bijl

Although for decades sunlight was suspected to be involved in the development of cutaneous lupus erythematosus (CLE), only in recent years research on the effects of ultraviolet irradiation on the skin of patients with CLE has resulted in a more comprehensive model for the pathogenesis of the disease. In this model, exposure to UV light induces apoptosis of keratinocytes and the release of pro-inflammatory cytokines. In susceptible patients, the presence or even accumulation of apoptotic cells results in the induction of characteristic inflammatory skin lesions, which might be due to a delayed and pro-inflammatory clearance of these apoptotic cells. Many other factors, in part genetically determined, are involved in CLE resulting in a very heterogeneous clinical manifestation. Among these factors, presence of autoantibodies, a decreased number of regulatory T cells at the site of inflammation and increased expression of pro-inflammatory cytokines like TNF alpha and IFN-inducible protein myxovirus protein A have been shown to play a role in the pathogenesis of CLE.

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalLupus
Volume17
Issue number5
Publication statusPublished - 2008
Event7th European Lupus Meeting - , Netherlands
Duration: 7-May-200810-May-2008

Event

7th European Lupus Meeting

07/05/200810/05/2008

Netherlands

Event: Other

    Keywords

  • REGULATORY T-CELLS, INFLAMMATORY SKIN-LESIONS, APOPTOTIC CELLS, ULTRAVIOLET-IRRADIATION, CLEARANCE, KERATINOCYTES, AUTOANTIGEN, EXPRESSION, SUNSCREENS, TOLERANCE

ID: 4727269