Publication

Pathogenesis of ANCA-associated vasculitis: recent insights from animal models

van Timmeren, M. M. & Heeringa, P., Jan-2012, In : CURRENT OPINION IN RHEUMATOLOGY. 24, 1, p. 8-14 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

van Timmeren, M. M., & Heeringa, P. (2012). Pathogenesis of ANCA-associated vasculitis: recent insights from animal models. CURRENT OPINION IN RHEUMATOLOGY, 24(1), 8-14. https://doi.org/10.1097/BOR.0b013e32834bde57

Author

van Timmeren, Mirjan M. ; Heeringa, Peter. / Pathogenesis of ANCA-associated vasculitis : recent insights from animal models. In: CURRENT OPINION IN RHEUMATOLOGY. 2012 ; Vol. 24, No. 1. pp. 8-14.

Harvard

van Timmeren, MM & Heeringa, P 2012, 'Pathogenesis of ANCA-associated vasculitis: recent insights from animal models', CURRENT OPINION IN RHEUMATOLOGY, vol. 24, no. 1, pp. 8-14. https://doi.org/10.1097/BOR.0b013e32834bde57

Standard

Pathogenesis of ANCA-associated vasculitis : recent insights from animal models. / van Timmeren, Mirjan M.; Heeringa, Peter.

In: CURRENT OPINION IN RHEUMATOLOGY, Vol. 24, No. 1, 01.2012, p. 8-14.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

van Timmeren MM, Heeringa P. Pathogenesis of ANCA-associated vasculitis: recent insights from animal models. CURRENT OPINION IN RHEUMATOLOGY. 2012 Jan;24(1):8-14. https://doi.org/10.1097/BOR.0b013e32834bde57


BibTeX

@article{82927ba37dbc43e2bcf5d021c4291f23,
title = "Pathogenesis of ANCA-associated vasculitis: recent insights from animal models",
abstract = "Purpose of reviewTo provide an update on animal models of antineutrophil cytoplasmic autoantibody (ANCA)-mediated vasculitis and highlight recent insights gained from studies in these models pertaining to immunopathogenesis.Recent findingsAnimal models support the pathogenic potential of myeloperoxidase (MPO)-ANCA. Alternative pathway complement activation has been identified as a novel inflammatory pathway in disease induction and a potential target for intervention. Interventions targeting B cells, antibodies, and signal transduction pathways may hold promise as well. The role of T cells is beginning to be explored, and studies indicate a prominent role for Th17 responses. The link between infection and ANCA vasculitis is well established. In animal models, Toll-like receptor (TLR)4 ligation is involved in disease induction. Ligation of TLRs contributes to the initiation of anti-MPO autoimmune responses in which TLR2 activation induces a Th17 response and TLR9 activation directs a Th1 response. An animal model for PR3-ANCA vasculitis is not available yet but models with a humanized immune system are being developed and show promising first results.SummaryAnimal models of MPO-ANCA vasculitis have contributed substantially to our understanding of disease immunopathogenesis and have illuminated novel targets for intervention. The development of PR3-ANCA animal models remains a challenge but recent observations in humanized model systems offer hope.",
keywords = "animal models, antineutrophil cytoplasmic autoantibodies, vasculitis, ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, IGG GLYCAN HYDROLYSIS, INTERACTIONS IN-VIVO, WEGENERS-GRANULOMATOSIS, ANTIMYELOPEROXIDASE ANTIBODIES, MEDIATED GLOMERULONEPHRITIS, HUMAN NEUTROPHILS, TH17 CELLS, AUTOANTIBODIES, MICE",
author = "{van Timmeren}, {Mirjan M.} and Peter Heeringa",
year = "2012",
month = "1",
doi = "10.1097/BOR.0b013e32834bde57",
language = "English",
volume = "24",
pages = "8--14",
journal = "CURRENT OPINION IN RHEUMATOLOGY",
issn = "1040-8711",
number = "1",

}

RIS

TY - JOUR

T1 - Pathogenesis of ANCA-associated vasculitis

T2 - recent insights from animal models

AU - van Timmeren, Mirjan M.

AU - Heeringa, Peter

PY - 2012/1

Y1 - 2012/1

N2 - Purpose of reviewTo provide an update on animal models of antineutrophil cytoplasmic autoantibody (ANCA)-mediated vasculitis and highlight recent insights gained from studies in these models pertaining to immunopathogenesis.Recent findingsAnimal models support the pathogenic potential of myeloperoxidase (MPO)-ANCA. Alternative pathway complement activation has been identified as a novel inflammatory pathway in disease induction and a potential target for intervention. Interventions targeting B cells, antibodies, and signal transduction pathways may hold promise as well. The role of T cells is beginning to be explored, and studies indicate a prominent role for Th17 responses. The link between infection and ANCA vasculitis is well established. In animal models, Toll-like receptor (TLR)4 ligation is involved in disease induction. Ligation of TLRs contributes to the initiation of anti-MPO autoimmune responses in which TLR2 activation induces a Th17 response and TLR9 activation directs a Th1 response. An animal model for PR3-ANCA vasculitis is not available yet but models with a humanized immune system are being developed and show promising first results.SummaryAnimal models of MPO-ANCA vasculitis have contributed substantially to our understanding of disease immunopathogenesis and have illuminated novel targets for intervention. The development of PR3-ANCA animal models remains a challenge but recent observations in humanized model systems offer hope.

AB - Purpose of reviewTo provide an update on animal models of antineutrophil cytoplasmic autoantibody (ANCA)-mediated vasculitis and highlight recent insights gained from studies in these models pertaining to immunopathogenesis.Recent findingsAnimal models support the pathogenic potential of myeloperoxidase (MPO)-ANCA. Alternative pathway complement activation has been identified as a novel inflammatory pathway in disease induction and a potential target for intervention. Interventions targeting B cells, antibodies, and signal transduction pathways may hold promise as well. The role of T cells is beginning to be explored, and studies indicate a prominent role for Th17 responses. The link between infection and ANCA vasculitis is well established. In animal models, Toll-like receptor (TLR)4 ligation is involved in disease induction. Ligation of TLRs contributes to the initiation of anti-MPO autoimmune responses in which TLR2 activation induces a Th17 response and TLR9 activation directs a Th1 response. An animal model for PR3-ANCA vasculitis is not available yet but models with a humanized immune system are being developed and show promising first results.SummaryAnimal models of MPO-ANCA vasculitis have contributed substantially to our understanding of disease immunopathogenesis and have illuminated novel targets for intervention. The development of PR3-ANCA animal models remains a challenge but recent observations in humanized model systems offer hope.

KW - animal models

KW - antineutrophil cytoplasmic autoantibodies

KW - vasculitis

KW - ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES

KW - IGG GLYCAN HYDROLYSIS

KW - INTERACTIONS IN-VIVO

KW - WEGENERS-GRANULOMATOSIS

KW - ANTIMYELOPEROXIDASE ANTIBODIES

KW - MEDIATED GLOMERULONEPHRITIS

KW - HUMAN NEUTROPHILS

KW - TH17 CELLS

KW - AUTOANTIBODIES

KW - MICE

U2 - 10.1097/BOR.0b013e32834bde57

DO - 10.1097/BOR.0b013e32834bde57

M3 - Review article

VL - 24

SP - 8

EP - 14

JO - CURRENT OPINION IN RHEUMATOLOGY

JF - CURRENT OPINION IN RHEUMATOLOGY

SN - 1040-8711

IS - 1

ER -

ID: 5464435