Publication

Parity and secondary progression in multiple sclerosis

Koch, M., Uyttenboogaart, M., Heersema, D., Steen, C. & De Keyser, J., Jun-2009, In : JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 80, 6, p. 676-678 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background: Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression.

Objective: To investigate the association of parity and secondary progression in women with MS.

Methods: The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders.

Results: Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression.

Conclusion: We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed.

Original languageEnglish
Pages (from-to)676-678
Number of pages3
JournalJOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Volume80
Issue number6
Publication statusPublished - Jun-2009

    Keywords

  • NATURAL-HISTORY, PREGNANCY, DISABILITY, DISEASE, PHASE, RISK

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