Publication

Parental Age in Relation to Offspring's Neurodevelopment

Veldkamp, S. A. M., Zondervan-Zwijnenburg, M. A. J., van Bergen, E., Barzeva, S. A., Tamayo-Martinez, N., Becht, A. I., van Beijsterveldt, C. E. M., Meeus, W., Branje, S., Hillegers, M. H. J., Oldehinkel, A. J., Hoijtink, H. J. A., Boomsma, D. I. & Hartman, C., 18-May-2020, In : Journal of Clinical Child and Adolescent Psychology. p. 1-13 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Veldkamp, S. A. M., Zondervan-Zwijnenburg, M. A. J., van Bergen, E., Barzeva, S. A., Tamayo-Martinez, N., Becht, A. I., van Beijsterveldt, C. E. M., Meeus, W., Branje, S., Hillegers, M. H. J., Oldehinkel, A. J., Hoijtink, H. J. A., Boomsma, D. I., & Hartman, C. (2020). Parental Age in Relation to Offspring's Neurodevelopment. Journal of Clinical Child and Adolescent Psychology, 1-13. https://doi.org/10.1080/15374416.2020.1756298

Author

Veldkamp, S A M ; Zondervan-Zwijnenburg, M A J ; van Bergen, Elsje ; Barzeva, S A ; Tamayo-Martinez, N ; Becht, A I ; van Beijsterveldt, C E M ; Meeus, W ; Branje, S ; Hillegers, M H J ; Oldehinkel, A J ; Hoijtink, H J A ; Boomsma, D I ; Hartman, C. / Parental Age in Relation to Offspring's Neurodevelopment. In: Journal of Clinical Child and Adolescent Psychology. 2020 ; pp. 1-13.

Harvard

Veldkamp, SAM, Zondervan-Zwijnenburg, MAJ, van Bergen, E, Barzeva, SA, Tamayo-Martinez, N, Becht, AI, van Beijsterveldt, CEM, Meeus, W, Branje, S, Hillegers, MHJ, Oldehinkel, AJ, Hoijtink, HJA, Boomsma, DI & Hartman, C 2020, 'Parental Age in Relation to Offspring's Neurodevelopment', Journal of Clinical Child and Adolescent Psychology, pp. 1-13. https://doi.org/10.1080/15374416.2020.1756298

Standard

Parental Age in Relation to Offspring's Neurodevelopment. / Veldkamp, S A M; Zondervan-Zwijnenburg, M A J; van Bergen, Elsje; Barzeva, S A; Tamayo-Martinez, N; Becht, A I; van Beijsterveldt, C E M; Meeus, W; Branje, S; Hillegers, M H J; Oldehinkel, A J; Hoijtink, H J A; Boomsma, D I; Hartman, C.

In: Journal of Clinical Child and Adolescent Psychology, 18.05.2020, p. 1-13.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Veldkamp SAM, Zondervan-Zwijnenburg MAJ, van Bergen E, Barzeva SA, Tamayo-Martinez N, Becht AI et al. Parental Age in Relation to Offspring's Neurodevelopment. Journal of Clinical Child and Adolescent Psychology. 2020 May 18;1-13. https://doi.org/10.1080/15374416.2020.1756298


BibTeX

@article{bc69ccab2ed24e9f9ae0f47276add6e8,
title = "Parental Age in Relation to Offspring's Neurodevelopment",
abstract = "Objective: Advanced parenthood increases the risk of severe neurodevelopmental disorders like autism, Down syndrome and schizophrenia. Does advanced parenthood also negatively impact offspring's general neurodevelopment?Method: We analyzed child-, father-, mother- and teacher-rated attention-problems (N = 38,024), and standardized measures of intelligence (N = 10,273) and educational achievement (N = 17,522) of children from four Dutch population-based cohorts. The mean age over cohorts varied from 9.73-13.03. Most participants were of Dutch origin, ranging from 58.7%-96.7% over cohorts. We analyzed 50% of the data to generate hypotheses and the other 50% to evaluate support for these hypotheses. We aggregated the results over cohorts with Bayesian research synthesis.Results: We mostly found negative linear relations between parental age and attention-problems, meaning that offspring of younger parents tended to have more attention problems. Maternal age was positively and linearly related to offspring's IQ and educational achievement. Paternal age showed an attenuating positive relation with educational achievement and an inverted U-shape relation with IQ, with offspring of younger and older fathers at a disadvantage. Only the associations with maternal age remained after including SES. The inclusion of child gender in the model did not affect the relation between parental age and the study outcomes.Conclusions: Effects were small but significant, with better outcomes for children born to older parents. Older parents tended to be of higher SES. Indeed, the positive relation between parental age and offspring neurodevelopmental outcomes was partly confounded by SES.",
keywords = "ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, PATERNAL AGE, MATERNAL AGE, ENVIRONMENT, RISK, LITERACY, ADHD",
author = "Veldkamp, {S A M} and Zondervan-Zwijnenburg, {M A J} and {van Bergen}, Elsje and Barzeva, {S A} and N Tamayo-Martinez and Becht, {A I} and {van Beijsterveldt}, {C E M} and W Meeus and S Branje and Hillegers, {M H J} and Oldehinkel, {A J} and Hoijtink, {H J A} and Boomsma, {D I} and C Hartman",
year = "2020",
month = may,
day = "18",
doi = "10.1080/15374416.2020.1756298",
language = "English",
pages = "1--13",
journal = "Journal of Clinical Child and Adolescent Psychology",
issn = "1537-4416",
publisher = "Routledge",

}

RIS

TY - JOUR

T1 - Parental Age in Relation to Offspring's Neurodevelopment

AU - Veldkamp, S A M

AU - Zondervan-Zwijnenburg, M A J

AU - van Bergen, Elsje

AU - Barzeva, S A

AU - Tamayo-Martinez, N

AU - Becht, A I

AU - van Beijsterveldt, C E M

AU - Meeus, W

AU - Branje, S

AU - Hillegers, M H J

AU - Oldehinkel, A J

AU - Hoijtink, H J A

AU - Boomsma, D I

AU - Hartman, C

PY - 2020/5/18

Y1 - 2020/5/18

N2 - Objective: Advanced parenthood increases the risk of severe neurodevelopmental disorders like autism, Down syndrome and schizophrenia. Does advanced parenthood also negatively impact offspring's general neurodevelopment?Method: We analyzed child-, father-, mother- and teacher-rated attention-problems (N = 38,024), and standardized measures of intelligence (N = 10,273) and educational achievement (N = 17,522) of children from four Dutch population-based cohorts. The mean age over cohorts varied from 9.73-13.03. Most participants were of Dutch origin, ranging from 58.7%-96.7% over cohorts. We analyzed 50% of the data to generate hypotheses and the other 50% to evaluate support for these hypotheses. We aggregated the results over cohorts with Bayesian research synthesis.Results: We mostly found negative linear relations between parental age and attention-problems, meaning that offspring of younger parents tended to have more attention problems. Maternal age was positively and linearly related to offspring's IQ and educational achievement. Paternal age showed an attenuating positive relation with educational achievement and an inverted U-shape relation with IQ, with offspring of younger and older fathers at a disadvantage. Only the associations with maternal age remained after including SES. The inclusion of child gender in the model did not affect the relation between parental age and the study outcomes.Conclusions: Effects were small but significant, with better outcomes for children born to older parents. Older parents tended to be of higher SES. Indeed, the positive relation between parental age and offspring neurodevelopmental outcomes was partly confounded by SES.

AB - Objective: Advanced parenthood increases the risk of severe neurodevelopmental disorders like autism, Down syndrome and schizophrenia. Does advanced parenthood also negatively impact offspring's general neurodevelopment?Method: We analyzed child-, father-, mother- and teacher-rated attention-problems (N = 38,024), and standardized measures of intelligence (N = 10,273) and educational achievement (N = 17,522) of children from four Dutch population-based cohorts. The mean age over cohorts varied from 9.73-13.03. Most participants were of Dutch origin, ranging from 58.7%-96.7% over cohorts. We analyzed 50% of the data to generate hypotheses and the other 50% to evaluate support for these hypotheses. We aggregated the results over cohorts with Bayesian research synthesis.Results: We mostly found negative linear relations between parental age and attention-problems, meaning that offspring of younger parents tended to have more attention problems. Maternal age was positively and linearly related to offspring's IQ and educational achievement. Paternal age showed an attenuating positive relation with educational achievement and an inverted U-shape relation with IQ, with offspring of younger and older fathers at a disadvantage. Only the associations with maternal age remained after including SES. The inclusion of child gender in the model did not affect the relation between parental age and the study outcomes.Conclusions: Effects were small but significant, with better outcomes for children born to older parents. Older parents tended to be of higher SES. Indeed, the positive relation between parental age and offspring neurodevelopmental outcomes was partly confounded by SES.

KW - ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

KW - PATERNAL AGE

KW - MATERNAL AGE

KW - ENVIRONMENT

KW - RISK

KW - LITERACY

KW - ADHD

U2 - 10.1080/15374416.2020.1756298

DO - 10.1080/15374416.2020.1756298

M3 - Article

C2 - 32420762

SP - 1

EP - 13

JO - Journal of Clinical Child and Adolescent Psychology

JF - Journal of Clinical Child and Adolescent Psychology

SN - 1537-4416

ER -

ID: 125484206