Publication

Oxygen Reserve Index: Validation of a New Variable

Vos, J. J., Willems, C. H., van Amsterdam, K., van den Berg, J. P., Spanjersberg, R., Struys, M. M. R. F. & Scheeren, T. W. L., Aug-2019, In : Anesthesia and Analgesia. 129, 2, p. 409-415 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Vos, J. J., Willems, C. H., van Amsterdam, K., van den Berg, J. P., Spanjersberg, R., Struys, M. M. R. F., & Scheeren, T. W. L. (2019). Oxygen Reserve Index: Validation of a New Variable. Anesthesia and Analgesia, 129(2), 409-415. https://doi.org/10.1213/ANE.0000000000003706

Author

Vos, Jaap Jan ; Willems, Cornelis H ; van Amsterdam, Kai ; van den Berg, Johannes P ; Spanjersberg, Rob ; Struys, Michel M R F ; Scheeren, Thomas W L. / Oxygen Reserve Index : Validation of a New Variable. In: Anesthesia and Analgesia. 2019 ; Vol. 129, No. 2. pp. 409-415.

Harvard

Vos, JJ, Willems, CH, van Amsterdam, K, van den Berg, JP, Spanjersberg, R, Struys, MMRF & Scheeren, TWL 2019, 'Oxygen Reserve Index: Validation of a New Variable', Anesthesia and Analgesia, vol. 129, no. 2, pp. 409-415. https://doi.org/10.1213/ANE.0000000000003706

Standard

Oxygen Reserve Index : Validation of a New Variable. / Vos, Jaap Jan; Willems, Cornelis H; van Amsterdam, Kai; van den Berg, Johannes P; Spanjersberg, Rob; Struys, Michel M R F; Scheeren, Thomas W L.

In: Anesthesia and Analgesia, Vol. 129, No. 2, 08.2019, p. 409-415.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Vos JJ, Willems CH, van Amsterdam K, van den Berg JP, Spanjersberg R, Struys MMRF et al. Oxygen Reserve Index: Validation of a New Variable. Anesthesia and Analgesia. 2019 Aug;129(2):409-415. https://doi.org/10.1213/ANE.0000000000003706


BibTeX

@article{6a39123de1f041eab8838d582b30126c,
title = "Oxygen Reserve Index: Validation of a New Variable",
abstract = "BACKGROUND: Pulse oximetry-derived oxygen saturation is typically >97% in normoxia and hyperoxia, limiting its clinical use. The new Oxygen Reserve Index (ORi), a relative indicator of the partial pressure of oxygen dissolved in arterial blood (PaO2) in the range of 100-200 mm Hg, may allow additional monitoring of oxygen status.METHODS: In this prospective validation intervention study, 20 healthy volunteers were breathing standardized oxygen concentrations ranging from mild hypoxia (fraction of inspired oxygen = 0.14) to hyperoxia (fraction of inspired oxygen = 1.0) via a tight-fitting face mask. ORi was measured noninvasively by multiwavelength pulse co-oximetry using 2 finger sensors. These ORi values (unitless scale, 0.00-1.00) were compared with measured PaO2 values. Repeated-measurements correlation analysis was performed to assess the ORi/PaO2 relationship. ORi trending ability was assessed using a 4-quadrant plot. The area under the receiver operating characteristics curve was calculated to assess the prediction of hypoxia (low-ranged PaO2, <100 mm Hg).RESULTS: Within the ORi-sensitive range, a strong positive correlation was found between ORi and PaO2 for both sensors (R = 0.78 and 0.83; P < .0001). ORi trending of PaO2 was good within this range (concordance rate = 94%). The prediction of PaO2 <100 mm Hg was also good, with an area under the receiver operating characteristics curve of 0.91 and 99% sensitivity and 82% specificity.CONCLUSIONS: In this prospective volunteer validation study, a strong and positive correlation between PaO2 and ORi was found, together with a good trending ability. Based on these data, the future use of ORi as a continuous noninvasive monitoring tool for assessing oxygenation status in patients receiving supplemental oxygen might be supported.",
keywords = "ANESTHESIA",
author = "Vos, {Jaap Jan} and Willems, {Cornelis H} and {van Amsterdam}, Kai and {van den Berg}, {Johannes P} and Rob Spanjersberg and Struys, {Michel M R F} and Scheeren, {Thomas W L}",
year = "2019",
month = aug,
doi = "10.1213/ANE.0000000000003706",
language = "English",
volume = "129",
pages = "409--415",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "2",

}

RIS

TY - JOUR

T1 - Oxygen Reserve Index

T2 - Validation of a New Variable

AU - Vos, Jaap Jan

AU - Willems, Cornelis H

AU - van Amsterdam, Kai

AU - van den Berg, Johannes P

AU - Spanjersberg, Rob

AU - Struys, Michel M R F

AU - Scheeren, Thomas W L

PY - 2019/8

Y1 - 2019/8

N2 - BACKGROUND: Pulse oximetry-derived oxygen saturation is typically >97% in normoxia and hyperoxia, limiting its clinical use. The new Oxygen Reserve Index (ORi), a relative indicator of the partial pressure of oxygen dissolved in arterial blood (PaO2) in the range of 100-200 mm Hg, may allow additional monitoring of oxygen status.METHODS: In this prospective validation intervention study, 20 healthy volunteers were breathing standardized oxygen concentrations ranging from mild hypoxia (fraction of inspired oxygen = 0.14) to hyperoxia (fraction of inspired oxygen = 1.0) via a tight-fitting face mask. ORi was measured noninvasively by multiwavelength pulse co-oximetry using 2 finger sensors. These ORi values (unitless scale, 0.00-1.00) were compared with measured PaO2 values. Repeated-measurements correlation analysis was performed to assess the ORi/PaO2 relationship. ORi trending ability was assessed using a 4-quadrant plot. The area under the receiver operating characteristics curve was calculated to assess the prediction of hypoxia (low-ranged PaO2, <100 mm Hg).RESULTS: Within the ORi-sensitive range, a strong positive correlation was found between ORi and PaO2 for both sensors (R = 0.78 and 0.83; P < .0001). ORi trending of PaO2 was good within this range (concordance rate = 94%). The prediction of PaO2 <100 mm Hg was also good, with an area under the receiver operating characteristics curve of 0.91 and 99% sensitivity and 82% specificity.CONCLUSIONS: In this prospective volunteer validation study, a strong and positive correlation between PaO2 and ORi was found, together with a good trending ability. Based on these data, the future use of ORi as a continuous noninvasive monitoring tool for assessing oxygenation status in patients receiving supplemental oxygen might be supported.

AB - BACKGROUND: Pulse oximetry-derived oxygen saturation is typically >97% in normoxia and hyperoxia, limiting its clinical use. The new Oxygen Reserve Index (ORi), a relative indicator of the partial pressure of oxygen dissolved in arterial blood (PaO2) in the range of 100-200 mm Hg, may allow additional monitoring of oxygen status.METHODS: In this prospective validation intervention study, 20 healthy volunteers were breathing standardized oxygen concentrations ranging from mild hypoxia (fraction of inspired oxygen = 0.14) to hyperoxia (fraction of inspired oxygen = 1.0) via a tight-fitting face mask. ORi was measured noninvasively by multiwavelength pulse co-oximetry using 2 finger sensors. These ORi values (unitless scale, 0.00-1.00) were compared with measured PaO2 values. Repeated-measurements correlation analysis was performed to assess the ORi/PaO2 relationship. ORi trending ability was assessed using a 4-quadrant plot. The area under the receiver operating characteristics curve was calculated to assess the prediction of hypoxia (low-ranged PaO2, <100 mm Hg).RESULTS: Within the ORi-sensitive range, a strong positive correlation was found between ORi and PaO2 for both sensors (R = 0.78 and 0.83; P < .0001). ORi trending of PaO2 was good within this range (concordance rate = 94%). The prediction of PaO2 <100 mm Hg was also good, with an area under the receiver operating characteristics curve of 0.91 and 99% sensitivity and 82% specificity.CONCLUSIONS: In this prospective volunteer validation study, a strong and positive correlation between PaO2 and ORi was found, together with a good trending ability. Based on these data, the future use of ORi as a continuous noninvasive monitoring tool for assessing oxygenation status in patients receiving supplemental oxygen might be supported.

KW - ANESTHESIA

U2 - 10.1213/ANE.0000000000003706

DO - 10.1213/ANE.0000000000003706

M3 - Article

C2 - 30138170

VL - 129

SP - 409

EP - 415

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 2

ER -

ID: 64529395