Publication

Ovarian cancer in BRCA1/2 mutation carriers: The impact of mutation position and family history on the cancer risk

Teixeira, N., Mourits, M. J. E., Vos, J. R., van der Kolk, D. M., Jansen, L., Oosterwijk, J. & de Bock, G. H., Oct-2015, In : Maturitas. 82, 2, p. 197-202 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Teixeira, N., Mourits, M. J. E., Vos, J. R., van der Kolk, D. M., Jansen, L., Oosterwijk, J., & de Bock, G. H. (2015). Ovarian cancer in BRCA1/2 mutation carriers: The impact of mutation position and family history on the cancer risk. Maturitas, 82(2), 197-202. https://doi.org/10.1016/j.maturitas.2015.07.001

Author

Teixeira, Natalja ; Mourits, Marian J. E. ; Vos, Janet R. ; van der Kolk, Donna M. ; Jansen, Liesbeth ; Oosterwijk, Jan ; de Bock, Geertruida H. / Ovarian cancer in BRCA1/2 mutation carriers : The impact of mutation position and family history on the cancer risk. In: Maturitas. 2015 ; Vol. 82, No. 2. pp. 197-202.

Harvard

Teixeira, N, Mourits, MJE, Vos, JR, van der Kolk, DM, Jansen, L, Oosterwijk, J & de Bock, GH 2015, 'Ovarian cancer in BRCA1/2 mutation carriers: The impact of mutation position and family history on the cancer risk', Maturitas, vol. 82, no. 2, pp. 197-202. https://doi.org/10.1016/j.maturitas.2015.07.001

Standard

Ovarian cancer in BRCA1/2 mutation carriers : The impact of mutation position and family history on the cancer risk. / Teixeira, Natalja; Mourits, Marian J. E.; Vos, Janet R.; van der Kolk, Donna M.; Jansen, Liesbeth; Oosterwijk, Jan; de Bock, Geertruida H.

In: Maturitas, Vol. 82, No. 2, 10.2015, p. 197-202.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Teixeira N, Mourits MJE, Vos JR, van der Kolk DM, Jansen L, Oosterwijk J et al. Ovarian cancer in BRCA1/2 mutation carriers: The impact of mutation position and family history on the cancer risk. Maturitas. 2015 Oct;82(2):197-202. https://doi.org/10.1016/j.maturitas.2015.07.001


BibTeX

@article{b575d3a9242045b4af0aa9c4948067b7,
title = "Ovarian cancer in BRCA1/2 mutation carriers: The impact of mutation position and family history on the cancer risk",
abstract = "Objectives: Assessing the combined impact of mutation position, regarding the ovarian cancer cluster region (OCCR), and type of cancer family history (FH) on age-related penetrance of ovarian cancer (OC) in women from BRCA/2 families from the northern Netherlands.Study design: A consecutive series of 1763 mutation carriers and their first-degree relatives from 355 proven BRCA1/2 families with a history of breast and/or ovarian cancer with in total 248 OC cases was included. Mutations were stratified for gene (BRCA1 or BRCA2) and location (within or outside the OCCR). FH was stratified for type of cancer occurring in first and second-degree relatives (OC only, breast cancer (BC) only or both OC and BC).Main outcome measures: Cox-proportional hazard models were applied to estimate the OCCR effect, including and excluding a FH of cancer.Results: Among BRCA1 families, OC risks were higher in women with OCCR mutations versus those with non-OCCR mutations (HR = 1.59, 95%CI = 1.19-2.12). This effect remained significant after adjustment for the type of FH (HR = 1.50, 95%CI = 1.11-2.01). In BRCA2 families, mutation position did not significantly affect the OC risk (HR = 1.50, 95%CI = 0.74-3.04). However, in the BRCA2 group, a FH including only OC presented by itself a strong impact on OC risk (HR = 4.63, 95%CI = 2.38-9.02), which remained stable after adjustment for mutation position (HR = 4.48, 95%CI = 2.28-8.81).Conclusion: OCCR mutations significantly increased the OC risk in BRCA1 families regardless of the type of FH, but in BRCA2 families, type of FH seems to have a higher impact than mutation position on OC risk. (C) 2015 Elsevier Ireland Ltd. All rights reserved.",
keywords = "Family history, OCCR, Ovarian cancer, Cancer risk estimation, REDUCING SALPINGO-OOPHORECTOMY, REGIONAL DIFFERENCES, BREAST-CANCER, WOMEN, METAANALYSIS, RELATIVES, SERIES, DUTCH, TIME, AGE",
author = "Natalja Teixeira and Mourits, {Marian J. E.} and Vos, {Janet R.} and {van der Kolk}, {Donna M.} and Liesbeth Jansen and Jan Oosterwijk and {de Bock}, {Geertruida H.}",
year = "2015",
month = oct,
doi = "10.1016/j.maturitas.2015.07.001",
language = "English",
volume = "82",
pages = "197--202",
journal = "Maturitas",
issn = "0378-5122",
publisher = "ELSEVIER IRELAND LTD",
number = "2",

}

RIS

TY - JOUR

T1 - Ovarian cancer in BRCA1/2 mutation carriers

T2 - The impact of mutation position and family history on the cancer risk

AU - Teixeira, Natalja

AU - Mourits, Marian J. E.

AU - Vos, Janet R.

AU - van der Kolk, Donna M.

AU - Jansen, Liesbeth

AU - Oosterwijk, Jan

AU - de Bock, Geertruida H.

PY - 2015/10

Y1 - 2015/10

N2 - Objectives: Assessing the combined impact of mutation position, regarding the ovarian cancer cluster region (OCCR), and type of cancer family history (FH) on age-related penetrance of ovarian cancer (OC) in women from BRCA/2 families from the northern Netherlands.Study design: A consecutive series of 1763 mutation carriers and their first-degree relatives from 355 proven BRCA1/2 families with a history of breast and/or ovarian cancer with in total 248 OC cases was included. Mutations were stratified for gene (BRCA1 or BRCA2) and location (within or outside the OCCR). FH was stratified for type of cancer occurring in first and second-degree relatives (OC only, breast cancer (BC) only or both OC and BC).Main outcome measures: Cox-proportional hazard models were applied to estimate the OCCR effect, including and excluding a FH of cancer.Results: Among BRCA1 families, OC risks were higher in women with OCCR mutations versus those with non-OCCR mutations (HR = 1.59, 95%CI = 1.19-2.12). This effect remained significant after adjustment for the type of FH (HR = 1.50, 95%CI = 1.11-2.01). In BRCA2 families, mutation position did not significantly affect the OC risk (HR = 1.50, 95%CI = 0.74-3.04). However, in the BRCA2 group, a FH including only OC presented by itself a strong impact on OC risk (HR = 4.63, 95%CI = 2.38-9.02), which remained stable after adjustment for mutation position (HR = 4.48, 95%CI = 2.28-8.81).Conclusion: OCCR mutations significantly increased the OC risk in BRCA1 families regardless of the type of FH, but in BRCA2 families, type of FH seems to have a higher impact than mutation position on OC risk. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

AB - Objectives: Assessing the combined impact of mutation position, regarding the ovarian cancer cluster region (OCCR), and type of cancer family history (FH) on age-related penetrance of ovarian cancer (OC) in women from BRCA/2 families from the northern Netherlands.Study design: A consecutive series of 1763 mutation carriers and their first-degree relatives from 355 proven BRCA1/2 families with a history of breast and/or ovarian cancer with in total 248 OC cases was included. Mutations were stratified for gene (BRCA1 or BRCA2) and location (within or outside the OCCR). FH was stratified for type of cancer occurring in first and second-degree relatives (OC only, breast cancer (BC) only or both OC and BC).Main outcome measures: Cox-proportional hazard models were applied to estimate the OCCR effect, including and excluding a FH of cancer.Results: Among BRCA1 families, OC risks were higher in women with OCCR mutations versus those with non-OCCR mutations (HR = 1.59, 95%CI = 1.19-2.12). This effect remained significant after adjustment for the type of FH (HR = 1.50, 95%CI = 1.11-2.01). In BRCA2 families, mutation position did not significantly affect the OC risk (HR = 1.50, 95%CI = 0.74-3.04). However, in the BRCA2 group, a FH including only OC presented by itself a strong impact on OC risk (HR = 4.63, 95%CI = 2.38-9.02), which remained stable after adjustment for mutation position (HR = 4.48, 95%CI = 2.28-8.81).Conclusion: OCCR mutations significantly increased the OC risk in BRCA1 families regardless of the type of FH, but in BRCA2 families, type of FH seems to have a higher impact than mutation position on OC risk. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

KW - Family history

KW - OCCR

KW - Ovarian cancer

KW - Cancer risk estimation

KW - REDUCING SALPINGO-OOPHORECTOMY

KW - REGIONAL DIFFERENCES

KW - BREAST-CANCER

KW - WOMEN

KW - METAANALYSIS

KW - RELATIVES

KW - SERIES

KW - DUTCH

KW - TIME

KW - AGE

U2 - 10.1016/j.maturitas.2015.07.001

DO - 10.1016/j.maturitas.2015.07.001

M3 - Article

VL - 82

SP - 197

EP - 202

JO - Maturitas

JF - Maturitas

SN - 0378-5122

IS - 2

ER -

ID: 25550560