Publication

Oromucosal films: from patient centricity to production by printing techniques

Tian, Y., Orlu, M., Woerdenbag, H. J., Scarpa, M., Kiefer, O., Kottke, D., Sjoholm, E., Oblom, H., Sandler, N., Hinrichs, W. L. J., Frijlink, H. W., Breitkreutz, J. & Visser, J. C., 2019, In : Expert Opinion on Drug Delivery. 16, 9, p. 981-993 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Tian, Y., Orlu, M., Woerdenbag, H. J., Scarpa, M., Kiefer, O., Kottke, D., Sjoholm, E., Oblom, H., Sandler, N., Hinrichs, W. L. J., Frijlink, H. W., Breitkreutz, J., & Visser, J. C. (2019). Oromucosal films: from patient centricity to production by printing techniques. Expert Opinion on Drug Delivery, 16(9), 981-993. https://doi.org/10.1080/17425247.2019.1652595

Author

Tian, Yu ; Orlu, Mine ; Woerdenbag, Herman J. ; Scarpa, Mariagiovanna ; Kiefer, Olga ; Kottke, Dina ; Sjoholm, Erica ; Oblom, Heidi ; Sandler, Niklas ; Hinrichs, Wouter L. J. ; Frijlink, Henderik W. ; Breitkreutz, Jorg ; Visser, J. Carolina. / Oromucosal films : from patient centricity to production by printing techniques. In: Expert Opinion on Drug Delivery. 2019 ; Vol. 16, No. 9. pp. 981-993.

Harvard

Tian, Y, Orlu, M, Woerdenbag, HJ, Scarpa, M, Kiefer, O, Kottke, D, Sjoholm, E, Oblom, H, Sandler, N, Hinrichs, WLJ, Frijlink, HW, Breitkreutz, J & Visser, JC 2019, 'Oromucosal films: from patient centricity to production by printing techniques', Expert Opinion on Drug Delivery, vol. 16, no. 9, pp. 981-993. https://doi.org/10.1080/17425247.2019.1652595

Standard

Oromucosal films : from patient centricity to production by printing techniques. / Tian, Yu; Orlu, Mine; Woerdenbag, Herman J.; Scarpa, Mariagiovanna; Kiefer, Olga; Kottke, Dina; Sjoholm, Erica; Oblom, Heidi; Sandler, Niklas; Hinrichs, Wouter L. J.; Frijlink, Henderik W.; Breitkreutz, Jorg; Visser, J. Carolina.

In: Expert Opinion on Drug Delivery, Vol. 16, No. 9, 2019, p. 981-993.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Tian Y, Orlu M, Woerdenbag HJ, Scarpa M, Kiefer O, Kottke D et al. Oromucosal films: from patient centricity to production by printing techniques. Expert Opinion on Drug Delivery. 2019;16(9):981-993. https://doi.org/10.1080/17425247.2019.1652595


BibTeX

@article{4b2650a8a6f149b38e8987b80d25f1e6,
title = "Oromucosal films: from patient centricity to production by printing techniques",
abstract = "Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.",
keywords = "Local drug delivery, mucoadhesive buccal films, orodispersible films, oromucosal films, patient centricity, printing techniques, systemic drug delivery, MUCOADHESIVE BUCCAL FILMS, CRITICAL MATERIAL ATTRIBUTES, IN-VITRO EVALUATION, ORAL DOSAGE FORMS, ORODISPERSIBLE FILMS, DRUG NANOPARTICLES, VIVO EVALUATION, BUCCOADHESIVE FILM, DELIVERY-SYSTEM, FORMULATION",
author = "Yu Tian and Mine Orlu and Woerdenbag, {Herman J.} and Mariagiovanna Scarpa and Olga Kiefer and Dina Kottke and Erica Sjoholm and Heidi Oblom and Niklas Sandler and Hinrichs, {Wouter L. J.} and Frijlink, {Henderik W.} and Jorg Breitkreutz and Visser, {J. Carolina}",
year = "2019",
doi = "10.1080/17425247.2019.1652595",
language = "English",
volume = "16",
pages = "981--993",
journal = "Expert Opinion on Drug Delivery",
issn = "1742-5247",
publisher = "Taylor and Francis Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - Oromucosal films

T2 - from patient centricity to production by printing techniques

AU - Tian, Yu

AU - Orlu, Mine

AU - Woerdenbag, Herman J.

AU - Scarpa, Mariagiovanna

AU - Kiefer, Olga

AU - Kottke, Dina

AU - Sjoholm, Erica

AU - Oblom, Heidi

AU - Sandler, Niklas

AU - Hinrichs, Wouter L. J.

AU - Frijlink, Henderik W.

AU - Breitkreutz, Jorg

AU - Visser, J. Carolina

PY - 2019

Y1 - 2019

N2 - Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

AB - Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

KW - Local drug delivery

KW - mucoadhesive buccal films

KW - orodispersible films

KW - oromucosal films

KW - patient centricity

KW - printing techniques

KW - systemic drug delivery

KW - MUCOADHESIVE BUCCAL FILMS

KW - CRITICAL MATERIAL ATTRIBUTES

KW - IN-VITRO EVALUATION

KW - ORAL DOSAGE FORMS

KW - ORODISPERSIBLE FILMS

KW - DRUG NANOPARTICLES

KW - VIVO EVALUATION

KW - BUCCOADHESIVE FILM

KW - DELIVERY-SYSTEM

KW - FORMULATION

U2 - 10.1080/17425247.2019.1652595

DO - 10.1080/17425247.2019.1652595

M3 - Review article

VL - 16

SP - 981

EP - 993

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

SN - 1742-5247

IS - 9

ER -

ID: 95744276