Publication

Oromucosal film preparations: Points to consider for patient centricity and manufacturing processes

Krampe, R., Visser, C., Frijlink, H. W., Breitkreutz, J., Woerdenbag, H. J. & Preis, M., 2-Apr-2016, In : Expert Opinion on Drug Delivery. 13, 4, p. 493-506 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Krampe, R., Visser, C., Frijlink, H. W., Breitkreutz, J., Woerdenbag, H. J., & Preis, M. (2016). Oromucosal film preparations: Points to consider for patient centricity and manufacturing processes. Expert Opinion on Drug Delivery, 13(4), 493-506. https://doi.org/10.1517/17425247.2016.1118048

Author

Krampe, Raphael ; Visser, Caroline ; Frijlink, Henderik W ; Breitkreutz, Jörg ; Woerdenbag, Herman J ; Preis, Maren. / Oromucosal film preparations : Points to consider for patient centricity and manufacturing processes. In: Expert Opinion on Drug Delivery. 2016 ; Vol. 13, No. 4. pp. 493-506.

Harvard

Krampe, R, Visser, C, Frijlink, HW, Breitkreutz, J, Woerdenbag, HJ & Preis, M 2016, 'Oromucosal film preparations: Points to consider for patient centricity and manufacturing processes', Expert Opinion on Drug Delivery, vol. 13, no. 4, pp. 493-506. https://doi.org/10.1517/17425247.2016.1118048

Standard

Oromucosal film preparations : Points to consider for patient centricity and manufacturing processes. / Krampe, Raphael; Visser, Caroline; Frijlink, Henderik W; Breitkreutz, Jörg; Woerdenbag, Herman J; Preis, Maren.

In: Expert Opinion on Drug Delivery, Vol. 13, No. 4, 02.04.2016, p. 493-506.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Krampe R, Visser C, Frijlink HW, Breitkreutz J, Woerdenbag HJ, Preis M. Oromucosal film preparations: Points to consider for patient centricity and manufacturing processes. Expert Opinion on Drug Delivery. 2016 Apr 2;13(4):493-506. https://doi.org/10.1517/17425247.2016.1118048


BibTeX

@article{d3a8ffcf1be34d78812611a429d0a876,
title = "Oromucosal film preparations: Points to consider for patient centricity and manufacturing processes",
abstract = "INTRODUCTION: According to the European Pharmacopoeia, oromucosal films comprise mucoadhesive buccal films and orodispersible films. Both oral dosage forms receive considerable interest in the recent years as commercially available pharmaceutical products and as small scale personalized extemporaneous preparations. Areas covered: In this review, technological issues such as viscosity of the casting liquid, mechanical properties of the film, upscaling and the stability of the casting solution and produced films will be discussed. Furthermore, patient-related problems like appearance, mucosal irritation, taste, drug load, safety and biopharmaceutics are described. Current knowledge and directions for solutions are summarized. Expert opinion: The viscosity of the casting solution is a key factor for producing suitable films. This parameter is amongst others dependent on the polymer and active pharmaceutical ingredient, and the further excipients that are used. For optimal patient compliance, an acceptable taste and palatability are desirable. Safe and inert excipients should be used and appropriate packaging should be provided to produced films. Absorption through the oral mucosa will vary for each active compound, formulation and patient, which gives rise to pharmacokinetic questions. Finally, the European Pharmacopoeia needs to specify methods, requirement and definitions for oromucosal film preparations based on bio-relevant data.",
keywords = "MUCOADHESIVE BUCCAL FILMS, DRUG-DELIVERY-SYSTEMS, ORAL DOSAGE FORMS, ORODISPERSIBLE FILMS, POLYMERIC FILMS, VIVO EVALUATION, SOLUBLE FILM, BIOADHESIVE FILMS, IN-VITRO, FORMULATION",
author = "Raphael Krampe and Caroline Visser and Frijlink, {Henderik W} and J{\"o}rg Breitkreutz and Woerdenbag, {Herman J} and Maren Preis",
year = "2016",
month = apr,
day = "2",
doi = "10.1517/17425247.2016.1118048",
language = "English",
volume = "13",
pages = "493--506",
journal = "Expert Opinion on Drug Delivery",
issn = "1742-5247",
publisher = "Taylor and Francis Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Oromucosal film preparations

T2 - Points to consider for patient centricity and manufacturing processes

AU - Krampe, Raphael

AU - Visser, Caroline

AU - Frijlink, Henderik W

AU - Breitkreutz, Jörg

AU - Woerdenbag, Herman J

AU - Preis, Maren

PY - 2016/4/2

Y1 - 2016/4/2

N2 - INTRODUCTION: According to the European Pharmacopoeia, oromucosal films comprise mucoadhesive buccal films and orodispersible films. Both oral dosage forms receive considerable interest in the recent years as commercially available pharmaceutical products and as small scale personalized extemporaneous preparations. Areas covered: In this review, technological issues such as viscosity of the casting liquid, mechanical properties of the film, upscaling and the stability of the casting solution and produced films will be discussed. Furthermore, patient-related problems like appearance, mucosal irritation, taste, drug load, safety and biopharmaceutics are described. Current knowledge and directions for solutions are summarized. Expert opinion: The viscosity of the casting solution is a key factor for producing suitable films. This parameter is amongst others dependent on the polymer and active pharmaceutical ingredient, and the further excipients that are used. For optimal patient compliance, an acceptable taste and palatability are desirable. Safe and inert excipients should be used and appropriate packaging should be provided to produced films. Absorption through the oral mucosa will vary for each active compound, formulation and patient, which gives rise to pharmacokinetic questions. Finally, the European Pharmacopoeia needs to specify methods, requirement and definitions for oromucosal film preparations based on bio-relevant data.

AB - INTRODUCTION: According to the European Pharmacopoeia, oromucosal films comprise mucoadhesive buccal films and orodispersible films. Both oral dosage forms receive considerable interest in the recent years as commercially available pharmaceutical products and as small scale personalized extemporaneous preparations. Areas covered: In this review, technological issues such as viscosity of the casting liquid, mechanical properties of the film, upscaling and the stability of the casting solution and produced films will be discussed. Furthermore, patient-related problems like appearance, mucosal irritation, taste, drug load, safety and biopharmaceutics are described. Current knowledge and directions for solutions are summarized. Expert opinion: The viscosity of the casting solution is a key factor for producing suitable films. This parameter is amongst others dependent on the polymer and active pharmaceutical ingredient, and the further excipients that are used. For optimal patient compliance, an acceptable taste and palatability are desirable. Safe and inert excipients should be used and appropriate packaging should be provided to produced films. Absorption through the oral mucosa will vary for each active compound, formulation and patient, which gives rise to pharmacokinetic questions. Finally, the European Pharmacopoeia needs to specify methods, requirement and definitions for oromucosal film preparations based on bio-relevant data.

KW - MUCOADHESIVE BUCCAL FILMS

KW - DRUG-DELIVERY-SYSTEMS

KW - ORAL DOSAGE FORMS

KW - ORODISPERSIBLE FILMS

KW - POLYMERIC FILMS

KW - VIVO EVALUATION

KW - SOLUBLE FILM

KW - BIOADHESIVE FILMS

KW - IN-VITRO

KW - FORMULATION

U2 - 10.1517/17425247.2016.1118048

DO - 10.1517/17425247.2016.1118048

M3 - Review article

C2 - 26559519

VL - 13

SP - 493

EP - 506

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

SN - 1742-5247

IS - 4

ER -

ID: 26964847