Publication

Organophosphorus pesticide poisoning: cases and developments

Aardema, H., Ligtenberg, J. J. M., Peters-Polman, O. M., Tulleken, J. E., Zijlstra, J. G. & Meertens, J. H. J. M., Apr-2008, In : Netherlands Journal of Medicine. 66, 4, p. 149-153 5 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Self-poisoning with organophosphate pesticides is a major health problem world-wide. Through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. Other manifestations are the intermediate neurotoxic syndrome and delayed polyneuropathy.

In the Western world, the occurrence of organophosphorus poisoning is less prevalent due to the declining availability of organophosphate pesticides, which could render the recognition of this particular type of intoxication and its specific treatment more difficult.

In this article we discuss some recent developments and treatment dilemmas, illustrated by cases from our clinic, followed by a review of the current recommendations in the treatment of organophosphate poisoning.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalNetherlands Journal of Medicine
Volume66
Issue number4
Publication statusPublished - Apr-2008

    Keywords

  • diagnosis, intoxication, oximes, parathion, treatment, CHOLINESTERASE INHIBITION, SECONDARY CONTAMINATION, DEVELOPING-WORLD, OXIME THERAPY, PRALIDOXIME, MANAGEMENT

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