Publication

Organellar Na+/H+ Exchangers: Novel Players in Organelle pH Regulation and Their Emerging Functions

Ohgaki, R., van Ijzendoorn, S. C. D., Matsushita, M., Hoekstra, D. & Kanazawa, H., 1-Feb-2011, In : Biochemistry. 50, 4, p. 443-450 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Ohgaki, R., van Ijzendoorn, S. C. D., Matsushita, M., Hoekstra, D., & Kanazawa, H. (2011). Organellar Na+/H+ Exchangers: Novel Players in Organelle pH Regulation and Their Emerging Functions. Biochemistry, 50(4), 443-450. https://doi.org/10.1021/bi101082e

Author

Ohgaki, Ryuichi ; van Ijzendoorn, Sven C. D. ; Matsushita, Masafumi ; Hoekstra, Dick ; Kanazawa, Hiroshi. / Organellar Na+/H+ Exchangers : Novel Players in Organelle pH Regulation and Their Emerging Functions. In: Biochemistry. 2011 ; Vol. 50, No. 4. pp. 443-450.

Harvard

Ohgaki, R, van Ijzendoorn, SCD, Matsushita, M, Hoekstra, D & Kanazawa, H 2011, 'Organellar Na+/H+ Exchangers: Novel Players in Organelle pH Regulation and Their Emerging Functions', Biochemistry, vol. 50, no. 4, pp. 443-450. https://doi.org/10.1021/bi101082e

Standard

Organellar Na+/H+ Exchangers : Novel Players in Organelle pH Regulation and Their Emerging Functions. / Ohgaki, Ryuichi; van Ijzendoorn, Sven C. D.; Matsushita, Masafumi; Hoekstra, Dick; Kanazawa, Hiroshi.

In: Biochemistry, Vol. 50, No. 4, 01.02.2011, p. 443-450.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Ohgaki R, van Ijzendoorn SCD, Matsushita M, Hoekstra D, Kanazawa H. Organellar Na+/H+ Exchangers: Novel Players in Organelle pH Regulation and Their Emerging Functions. Biochemistry. 2011 Feb 1;50(4):443-450. https://doi.org/10.1021/bi101082e


BibTeX

@article{dc40b7a1e21444daacdce9d68388497c,
title = "Organellar Na+/H+ Exchangers: Novel Players in Organelle pH Regulation and Their Emerging Functions",
abstract = "Mammalian Na+/H+ exchangers (NHEs) play a fundamental role in cellular ion homeostasis. NHEs exhibit an appreciable variation in expression, regulation, and physiological function, dictated by their dynamics in subcellular localization and/or interaction with regulatory proteins. In recent years, a subgroup of NHEs consisting of four isoforms has been identified, and its members predominantly localize to the membranes of the Golgi apparatus and endosoines. These organellar NHEs constitute a family of transporters with an emerging function in the regulation of luminal pH and in intracellular membrane trafficking as expressed, for example, in cell polarity development. Moreover, specific roles of a variety of cofactors, regulating the intracellular dynamics of these transporters, are also becoming apparent, thereby providing further insight into their mechanism of action and overall functioning. Interestingly, organellar NHEs have been related to mental disorders, implying a potential role in the brain, thus expanding the physiological significance of these transporters.",
keywords = "TRANS-GOLGI NETWORK, CANINE KIDNEY-CELLS, INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR, PROTEIN-KINASE-C, SODIUM/PROTON EXCHANGER, ANGELMAN-SYNDROME, INFLUENZA M2, SELECTIVE PERTURBATION, SUBAPICAL COMPARTMENT, RECYCLING ENDOSOMES",
author = "Ryuichi Ohgaki and {van Ijzendoorn}, {Sven C. D.} and Masafumi Matsushita and Dick Hoekstra and Hiroshi Kanazawa",
year = "2011",
month = "2",
day = "1",
doi = "10.1021/bi101082e",
language = "English",
volume = "50",
pages = "443--450",
journal = "Biochemistry",
issn = "0006-2960",
publisher = "AMER CHEMICAL SOC",
number = "4",

}

RIS

TY - JOUR

T1 - Organellar Na+/H+ Exchangers

T2 - Novel Players in Organelle pH Regulation and Their Emerging Functions

AU - Ohgaki, Ryuichi

AU - van Ijzendoorn, Sven C. D.

AU - Matsushita, Masafumi

AU - Hoekstra, Dick

AU - Kanazawa, Hiroshi

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Mammalian Na+/H+ exchangers (NHEs) play a fundamental role in cellular ion homeostasis. NHEs exhibit an appreciable variation in expression, regulation, and physiological function, dictated by their dynamics in subcellular localization and/or interaction with regulatory proteins. In recent years, a subgroup of NHEs consisting of four isoforms has been identified, and its members predominantly localize to the membranes of the Golgi apparatus and endosoines. These organellar NHEs constitute a family of transporters with an emerging function in the regulation of luminal pH and in intracellular membrane trafficking as expressed, for example, in cell polarity development. Moreover, specific roles of a variety of cofactors, regulating the intracellular dynamics of these transporters, are also becoming apparent, thereby providing further insight into their mechanism of action and overall functioning. Interestingly, organellar NHEs have been related to mental disorders, implying a potential role in the brain, thus expanding the physiological significance of these transporters.

AB - Mammalian Na+/H+ exchangers (NHEs) play a fundamental role in cellular ion homeostasis. NHEs exhibit an appreciable variation in expression, regulation, and physiological function, dictated by their dynamics in subcellular localization and/or interaction with regulatory proteins. In recent years, a subgroup of NHEs consisting of four isoforms has been identified, and its members predominantly localize to the membranes of the Golgi apparatus and endosoines. These organellar NHEs constitute a family of transporters with an emerging function in the regulation of luminal pH and in intracellular membrane trafficking as expressed, for example, in cell polarity development. Moreover, specific roles of a variety of cofactors, regulating the intracellular dynamics of these transporters, are also becoming apparent, thereby providing further insight into their mechanism of action and overall functioning. Interestingly, organellar NHEs have been related to mental disorders, implying a potential role in the brain, thus expanding the physiological significance of these transporters.

KW - TRANS-GOLGI NETWORK

KW - CANINE KIDNEY-CELLS

KW - INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR

KW - PROTEIN-KINASE-C

KW - SODIUM/PROTON EXCHANGER

KW - ANGELMAN-SYNDROME

KW - INFLUENZA M2

KW - SELECTIVE PERTURBATION

KW - SUBAPICAL COMPARTMENT

KW - RECYCLING ENDOSOMES

U2 - 10.1021/bi101082e

DO - 10.1021/bi101082e

M3 - Article

VL - 50

SP - 443

EP - 450

JO - Biochemistry

JF - Biochemistry

SN - 0006-2960

IS - 4

ER -

ID: 5250939