Publication

Organellar Na+/H+ Exchangers: Novel Players in Organelle pH Regulation and Their Emerging Functions

Ohgaki, R., van Ijzendoorn, S. C. D., Matsushita, M., Hoekstra, D. & Kanazawa, H., 1-Feb-2011, In : Biochemistry. 50, 4, p. 443-450 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Mammalian Na+/H+ exchangers (NHEs) play a fundamental role in cellular ion homeostasis. NHEs exhibit an appreciable variation in expression, regulation, and physiological function, dictated by their dynamics in subcellular localization and/or interaction with regulatory proteins. In recent years, a subgroup of NHEs consisting of four isoforms has been identified, and its members predominantly localize to the membranes of the Golgi apparatus and endosoines. These organellar NHEs constitute a family of transporters with an emerging function in the regulation of luminal pH and in intracellular membrane trafficking as expressed, for example, in cell polarity development. Moreover, specific roles of a variety of cofactors, regulating the intracellular dynamics of these transporters, are also becoming apparent, thereby providing further insight into their mechanism of action and overall functioning. Interestingly, organellar NHEs have been related to mental disorders, implying a potential role in the brain, thus expanding the physiological significance of these transporters.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalBiochemistry
Volume50
Issue number4
Publication statusPublished - 1-Feb-2011

    Keywords

  • TRANS-GOLGI NETWORK, CANINE KIDNEY-CELLS, INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR, PROTEIN-KINASE-C, SODIUM/PROTON EXCHANGER, ANGELMAN-SYNDROME, INFLUENZA M2, SELECTIVE PERTURBATION, SUBAPICAL COMPARTMENT, RECYCLING ENDOSOMES

ID: 5250939