Onset of hypothyroidism after total laryngectomy: Effects of thyroid gland surgery and preoperative and postoperative radiotherapy

Plaat, R. E., van Dijk, B. A. C., Muller Kobold, A. C., Steenbakkers, R. J. H. M., Links, T. P., van der Laan, B. F. A. M. & Plaat, B. E. C., 13-Dec-2019, In : Journal of the Sciences and Specialties of the Head and Neck. 42, 4, p. 636-644 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard



BACKGROUND: To determine time of onset and risk of hypothyroidism after total laryngectomy (TL) with and without (hemi)thyroidectomy in relation to treatment regimen, that is, preoperative radiotherapy (RT-TL), postoperative radiotherapy (TL-RT), and postoperative re-irradiation (RT-TL-RT).

METHODS: Retrospective review of 128 patients treated by RT-TL (51 patients), TL-RT (55 patients), and RT-TL-RT (22 patients). Risk of hypothyroidism was determined by multivariable Cox regression analysis and euthyroid survival was calculated using Kaplan-Meier method.

RESULTS: Hypothyroidism developed in 69 (54%) patients. The median onset of hypothyroidism was later (P < .01) and the risk of hypothyroidism was lower (hazard ratio 0.49; P = .014) in the TL-RT group compared to both other treatment regimens. Euthyroid survival did not differ between the treatment regimens. Two years euthyroid survival was 24% with and 61% without (hemi)thyroidectomy (P < .001).

CONCLUSIONS: Patients treated with TL-RT have later onset of hypothyroidism. Higher risk for hypothyroidism is associated with salvage TL after radiotherapy and (hemi)thyroidectomy.

Original languageEnglish
Pages (from-to)636-644
Number of pages9
JournalJournal of the Sciences and Specialties of the Head and Neck
Issue number4
Publication statusE-pub ahead of print - 13-Dec-2019

Download statistics

No data available

ID: 109880298