Publication

One-pot, modular approach to functionalized ketones via nucleophilic addition/Buchwald-Hartwig amination strategy

de Jong, J., Heijnen, D., Helbert, H. & Feringa, B. L., 11-Mar-2019, In : Chemical Communications. 55, 20, p. 2908-2911 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

A general one-pot procedure for the 1,2-addition of organolithium reagents to amides followed by the Buchwald-Hartwig amination with in situ released lithium amides is presented. In this work amides are used as masked ketones, revealed by the addition of organolithium reagents which generates a lithium amide, suitable for subsequent Buchwald-Hartwig coupling in the presence of a palladium catalyst. This methodology allows for rapid, efficient and atom economic synthesis of aminoarylketones in good yields.

Original languageEnglish
Pages (from-to)2908-2911
Number of pages4
JournalChemical Communications
Volume55
Issue number20
Publication statusPublished - 11-Mar-2019

    Keywords

  • C-N, CATALYZED AMINATION, ARYL CHLORIDES, BROMIDES, INHIBITORS, REAGENTS, IODIDES, AMMONIA

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