One-pot, modular approach to functionalized ketones via nucleophilic addition/Buchwald-Hartwig amination strategyde Jong, J., Heijnen, D., Helbert, H. & Feringa, B. L., 11-Mar-2019, In : Chemical Communications. 55, 20, p. 2908-2911 4 p.
Research output: Contribution to journal › Article › Academic › peer-review
A general one-pot procedure for the 1,2-addition of organolithium reagents to amides followed by the Buchwald-Hartwig amination with in situ released lithium amides is presented. In this work amides are used as masked ketones, revealed by the addition of organolithium reagents which generates a lithium amide, suitable for subsequent Buchwald-Hartwig coupling in the presence of a palladium catalyst. This methodology allows for rapid, efficient and atom economic synthesis of aminoarylketones in good yields.
|Number of pages||4|
|Publication status||Published - 11-Mar-2019|
- C-N, CATALYZED AMINATION, ARYL CHLORIDES, BROMIDES, INHIBITORS, REAGENTS, IODIDES, AMMONIA