Publication

On the biogenesis of myelin membranes: Sorting, trafficking and cell polarity

Baron, W. & Hoekstra, D., 3-May-2010, In : FEBS Letters. 584, 9, p. 1760-1770 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

In the central nervous system, a multilayered membrane layer known as the myelin sheath enwraps axons, and is required for optimal saltatory signal conductance. The sheath develops from membrane processes that extend from the plasma membrane of oligodendrocytes and displays a unique lipid and protein composition. Myelin biogenesis is carefully regulated, and multiple transport pathways involving a variety of endosomal compartments are involved. Here we briefly summarize how the major myelin proteins proteolipid protein and myelin basic protein reach the sheath, and highlight potential mechanisms involved, including the role of myelin specific lipids and cell polarity related transport pathways. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Original languageEnglish
Pages (from-to)1760-1770
Number of pages11
JournalFEBS Letters
Volume584
Issue number9
Publication statusPublished - 3-May-2010

    Keywords

  • Myelin, Trafficking, Microdomain, Proteolipid protein, Myelin basic protein, Sorting, PELIZAEUS-MERZBACHER-DISEASE, CENTRAL-NERVOUS-SYSTEM, PROTEIN MESSENGER-RNA, A2 RESPONSE ELEMENT, BASIC-PROTEIN, PROTEOLIPID PROTEIN, OLIGODENDROCYTE DIFFERENTIATION, MULTIPLE-SCLEROSIS, CNS MYELINATION, CULTURED OLIGODENDROCYTES

ID: 5067709