Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging

Neves, J., Demaria, M., Campisi, J. & Jasper, H., 12-Jan-2015, In : Developmental Cell. 32, 1, p. 9-18 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Studies in flies, mice, and human models have provided a conceptual framework for how paracrine interactions between damaged cells and the surrounding tissue control tissue repair. These studies have amassed evidence for an evolutionarily conserved secretory program that regulates tissue homeostasis. This program coordinates cell survival and proliferation during tissue regeneration and repair in young animals. By virtue of chronic engagement, however, it also contributes to the age-related decline of tissue homeostasis leading to degeneration, metabolic dysfunction, and cancer. Here, we review recent studies that shed light on the nature and regulation of this evolutionarily conserved secretory program.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalDevelopmental Cell
Issue number1
Publication statusPublished - 12-Jan-2015
Externally publishedYes


  • Aging, Animals, Biological Evolution, Diptera, Homeostasis, Humans, Male, Mice, Wound Healing

ID: 26937577