Publication

Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands

van der Mark, M., Vermeulen, R., Nijssen, P. C. G., Mulleners, W. M., Sas, A. M. G., van Laar, T., Brouwer, M., Huss, A. & Kromhout, H., Nov-2014, In : OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 71, 11, p. 757-764 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van der Mark, M., Vermeulen, R., Nijssen, P. C. G., Mulleners, W. M., Sas, A. M. G., van Laar, T., ... Kromhout, H. (2014). Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 71(11), 757-764. https://doi.org/10.1136/oemed-2014-102170

Author

van der Mark, Marianne ; Vermeulen, Roel ; Nijssen, Peter C. G. ; Mulleners, Wim M. ; Sas, Antonetta M. G. ; van Laar, Teus ; Brouwer, Maartje ; Huss, Anke ; Kromhout, Hans. / Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands. In: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2014 ; Vol. 71, No. 11. pp. 757-764.

Harvard

van der Mark, M, Vermeulen, R, Nijssen, PCG, Mulleners, WM, Sas, AMG, van Laar, T, Brouwer, M, Huss, A & Kromhout, H 2014, 'Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands', OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, vol. 71, no. 11, pp. 757-764. https://doi.org/10.1136/oemed-2014-102170

Standard

Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands. / van der Mark, Marianne; Vermeulen, Roel; Nijssen, Peter C. G.; Mulleners, Wim M.; Sas, Antonetta M. G.; van Laar, Teus; Brouwer, Maartje; Huss, Anke; Kromhout, Hans.

In: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol. 71, No. 11, 11.2014, p. 757-764.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van der Mark M, Vermeulen R, Nijssen PCG, Mulleners WM, Sas AMG, van Laar T et al. Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2014 Nov;71(11):757-764. https://doi.org/10.1136/oemed-2014-102170


BibTeX

@article{da8d41ed599444f8ac57cc4fd9be6c8e,
title = "Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands",
abstract = "Objectives Previous research has indicated that occupational exposure to pesticides and possibly airborne endotoxin may increase the risk of developing Parkinson disease (PD). We studied the associations of PD with occupational exposure to pesticides, specifically to the functional subclasses insecticides, herbicides and fungicides, and to airborne endotoxin. In addition we evaluated specific pesticides (active ingredients) previously associated with PD.Methods We used data from a hospital-based case-control study, including 444 patients with PD and 876 age and sex matched controls. Exposures to pesticides from application and re-entry work were estimated with the ALOHA+job-exposure matrix and with an exposure algorithm based on self-reported information on pesticide use. To assess exposure to specific active ingredients a crop-exposure matrix was developed. Endotoxin exposure was estimated with the DOM job-exposure matrix.Results The results showed almost no significant associations. However, ORs were elevated in the higher exposure categories for pesticides in general, insecticides, herbicides and fungicides, and below unity for endotoxin exposure. The analyses on specific active ingredients showed a significant association of PD risk with the fungicide benomyl.Conclusions This study did not provide evidence for a relation between pesticide exposure and PD. However, the consistently elevated ORs in the higher exposure categories suggest that a positive association may exist. The possible association with the active ingredient benomyl requires follow-up in other studies. This study did not provide support for a possible association between endotoxin exposure and PD.",
keywords = "RISK, ASSOCIATION, POPULATION",
author = "{van der Mark}, Marianne and Roel Vermeulen and Nijssen, {Peter C. G.} and Mulleners, {Wim M.} and Sas, {Antonetta M. G.} and {van Laar}, Teus and Maartje Brouwer and Anke Huss and Hans Kromhout",
year = "2014",
month = "11",
doi = "10.1136/oemed-2014-102170",
language = "English",
volume = "71",
pages = "757--764",
journal = "OCCUPATIONAL AND ENVIRONMENTAL MEDICINE",
issn = "1351-0711",
publisher = "BMJ PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands

AU - van der Mark, Marianne

AU - Vermeulen, Roel

AU - Nijssen, Peter C. G.

AU - Mulleners, Wim M.

AU - Sas, Antonetta M. G.

AU - van Laar, Teus

AU - Brouwer, Maartje

AU - Huss, Anke

AU - Kromhout, Hans

PY - 2014/11

Y1 - 2014/11

N2 - Objectives Previous research has indicated that occupational exposure to pesticides and possibly airborne endotoxin may increase the risk of developing Parkinson disease (PD). We studied the associations of PD with occupational exposure to pesticides, specifically to the functional subclasses insecticides, herbicides and fungicides, and to airborne endotoxin. In addition we evaluated specific pesticides (active ingredients) previously associated with PD.Methods We used data from a hospital-based case-control study, including 444 patients with PD and 876 age and sex matched controls. Exposures to pesticides from application and re-entry work were estimated with the ALOHA+job-exposure matrix and with an exposure algorithm based on self-reported information on pesticide use. To assess exposure to specific active ingredients a crop-exposure matrix was developed. Endotoxin exposure was estimated with the DOM job-exposure matrix.Results The results showed almost no significant associations. However, ORs were elevated in the higher exposure categories for pesticides in general, insecticides, herbicides and fungicides, and below unity for endotoxin exposure. The analyses on specific active ingredients showed a significant association of PD risk with the fungicide benomyl.Conclusions This study did not provide evidence for a relation between pesticide exposure and PD. However, the consistently elevated ORs in the higher exposure categories suggest that a positive association may exist. The possible association with the active ingredient benomyl requires follow-up in other studies. This study did not provide support for a possible association between endotoxin exposure and PD.

AB - Objectives Previous research has indicated that occupational exposure to pesticides and possibly airborne endotoxin may increase the risk of developing Parkinson disease (PD). We studied the associations of PD with occupational exposure to pesticides, specifically to the functional subclasses insecticides, herbicides and fungicides, and to airborne endotoxin. In addition we evaluated specific pesticides (active ingredients) previously associated with PD.Methods We used data from a hospital-based case-control study, including 444 patients with PD and 876 age and sex matched controls. Exposures to pesticides from application and re-entry work were estimated with the ALOHA+job-exposure matrix and with an exposure algorithm based on self-reported information on pesticide use. To assess exposure to specific active ingredients a crop-exposure matrix was developed. Endotoxin exposure was estimated with the DOM job-exposure matrix.Results The results showed almost no significant associations. However, ORs were elevated in the higher exposure categories for pesticides in general, insecticides, herbicides and fungicides, and below unity for endotoxin exposure. The analyses on specific active ingredients showed a significant association of PD risk with the fungicide benomyl.Conclusions This study did not provide evidence for a relation between pesticide exposure and PD. However, the consistently elevated ORs in the higher exposure categories suggest that a positive association may exist. The possible association with the active ingredient benomyl requires follow-up in other studies. This study did not provide support for a possible association between endotoxin exposure and PD.

KW - RISK

KW - ASSOCIATION

KW - POPULATION

U2 - 10.1136/oemed-2014-102170

DO - 10.1136/oemed-2014-102170

M3 - Article

VL - 71

SP - 757

EP - 764

JO - OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

JF - OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

SN - 1351-0711

IS - 11

ER -

ID: 16114507