Publication

OBSTACLES IN THE APPLICATION OF MICROENCAPSULATION IN ISLET TRANSPLANTATION

DEVOS, P., WOLTERS, GHJ., FRITSCHY, WM. & VANSCHILFGAARDE, R., Apr-1993, In : International journal of artificial organs. 16, 4, p. 205-212 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • P DEVOS
  • GHJ WOLTERS
  • WM FRITSCHY
  • R VANSCHILFGAARDE

Several factors stand in the way of successful clinical transplantation of alginate-polylysine-alginate microencapsulated pancreatic islets. These obstacles can be classified into three categories. The first regards the technical aspects of the production process. Limiting factors are the insufficient ability to produce small capsules with an adequate production rate, and insufficient insight into the factors determining the optimal chemical and mechanical properties of the capsules. The second category regards the functional aspects of the microencapsulated islets, such as the limitations of the transplantation site and the absence of a physiologic insulin response of the encapsulated islets to elevated blood glucose levels. The third category regards the fact that survival times of encapsulated islet grafts are still limited to several weeks or months, which is mainly explained by a pericapsular fibrotic overgrowth reaction as a consequence of the bioincompatibility of the capsule membrane. This study describes these obstacles, and thereby summarizes the requirements needed for successful clinical application of encapsulated islet transplantation.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalInternational journal of artificial organs
Volume16
Issue number4
Publication statusPublished - Apr-1993

    Keywords

  • ALGINATE-POLYLYSINE, MICROENCAPSULATION, ISLET TRANSPLANTATION, DROPLET GENERATOR, PANCREATIC-ISLETS, RAT ISLETS, NOD MICE, ALGINATE, CELLS, REVERSAL, MICROCAPSULES, XENOGRAFTS, INVITRO, GLUCOSE

ID: 6352626