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Nucleobase recognition at alkaline pH and apparent pK(a) of single DNA bases immobilised within a biological nanopore

Fransceschini, L., Mikhailova, E., Bayley, H. & Maglia, G., 2012, In : Chemical Communications. 48, 10, p. 1520-1522 3 p.

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  • Nucleobase recognition at alkaline pH and apparent pK(a) of single DNA bases immobilised within a biological nanopore

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DOI

The four DNA bases are recognized in immobilized DNA strands at high alkaline pH by nanopore current recordings. Ionic currents through the biological nanopores are also employed to measure the apparent pK(a) values of single nucleobases within the immobilised DNA strands.
Original languageEnglish
Pages (from-to)1520-1522
Number of pages3
JournalChemical Communications
Volume48
Issue number10
Publication statusPublished - 2012

    Keywords

  • ion-channel, discrimination, denaturation, salt, RNA, translocation, protonation

ID: 36010124