Publication

Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction

Zhao, T., 2016, [Groningen]: Rijksuniversiteit Groningen. 317 p.

Research output: ThesisThesis fully internal (DIV)Academic

APA

Zhao, T. (2016). Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction. [Groningen]: Rijksuniversiteit Groningen.

Author

Zhao, Ting. / Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction. [Groningen] : Rijksuniversiteit Groningen, 2016. 317 p.

Harvard

Zhao, T 2016, 'Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction', Doctor of Philosophy, University of Groningen, [Groningen].

Standard

Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction. / Zhao, Ting.

[Groningen] : Rijksuniversiteit Groningen, 2016. 317 p.

Research output: ThesisThesis fully internal (DIV)Academic

Vancouver

Zhao T. Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction. [Groningen]: Rijksuniversiteit Groningen, 2016. 317 p.


BibTeX

@phdthesis{9c87b9481f22407599644b7bf96f39b9,
title = "Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction",
abstract = "The distinguished properties of tetrazole moiety make it possible to be employed as bioisosteric substituent of carboxylic acid in developing biological active substances. Tetrazole possesses several advantages over carboxylic acids with respect to many aspects including metabolic stability, electronic distribution, hydrogen bonding, and lipophilicity. These advantages facilitate the interactions between ligands and receptors, and potentially allow for a better cell membrane passage.The research presented in this thesis mainly focuses on introducing the tetrazole moiety as a structural fragment in the preparation of several series of drug-like molecules, and studies towards their related applications in pharmacology.Although many successful applications of the tetrazole in medicinal chemistry are presented, we can expect more investigations and discoveries in this field. For instance, it is attractive to further optimize the structures of the present drug molecules and develop feasible approaches for the preparation of tetrazole containing natural products by using multicomponent reactions. However, it is of the most importance to gain a good understanding of the pharmacophore and the physicochemical properties of the bioisosteres for the proper bioisosteric replacements with favorable attributes.",
author = "Ting Zhao",
year = "2016",
language = "English",
isbn = "978-90-367-8876-2",
publisher = "Rijksuniversiteit Groningen",
school = "University of Groningen",

}

RIS

TY - THES

T1 - Novel Applications of Tetrazoles Derived from the TMSN3-Ugi Reaction

AU - Zhao, Ting

PY - 2016

Y1 - 2016

N2 - The distinguished properties of tetrazole moiety make it possible to be employed as bioisosteric substituent of carboxylic acid in developing biological active substances. Tetrazole possesses several advantages over carboxylic acids with respect to many aspects including metabolic stability, electronic distribution, hydrogen bonding, and lipophilicity. These advantages facilitate the interactions between ligands and receptors, and potentially allow for a better cell membrane passage.The research presented in this thesis mainly focuses on introducing the tetrazole moiety as a structural fragment in the preparation of several series of drug-like molecules, and studies towards their related applications in pharmacology.Although many successful applications of the tetrazole in medicinal chemistry are presented, we can expect more investigations and discoveries in this field. For instance, it is attractive to further optimize the structures of the present drug molecules and develop feasible approaches for the preparation of tetrazole containing natural products by using multicomponent reactions. However, it is of the most importance to gain a good understanding of the pharmacophore and the physicochemical properties of the bioisosteres for the proper bioisosteric replacements with favorable attributes.

AB - The distinguished properties of tetrazole moiety make it possible to be employed as bioisosteric substituent of carboxylic acid in developing biological active substances. Tetrazole possesses several advantages over carboxylic acids with respect to many aspects including metabolic stability, electronic distribution, hydrogen bonding, and lipophilicity. These advantages facilitate the interactions between ligands and receptors, and potentially allow for a better cell membrane passage.The research presented in this thesis mainly focuses on introducing the tetrazole moiety as a structural fragment in the preparation of several series of drug-like molecules, and studies towards their related applications in pharmacology.Although many successful applications of the tetrazole in medicinal chemistry are presented, we can expect more investigations and discoveries in this field. For instance, it is attractive to further optimize the structures of the present drug molecules and develop feasible approaches for the preparation of tetrazole containing natural products by using multicomponent reactions. However, it is of the most importance to gain a good understanding of the pharmacophore and the physicochemical properties of the bioisosteres for the proper bioisosteric replacements with favorable attributes.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-8876-2

PB - Rijksuniversiteit Groningen

CY - [Groningen]

ER -

ID: 33027765