Non-Coding RNAs in Cancer Radiosensitivity: MicroRNAs and lncRNAs as Regulators of Radiation-Induced Signaling PathwaysPodralska, M., Ciesielska, S., Kluiver, J., van den Berg, A., Dzikiewicz-Krawczyk, A. & Slezak-Prochazka, I., 23-Jun-2020, In : Cancers. 12, 6, p. 1-27 27 p., 1662.
Research output: Contribution to journal › Review article › Academic › peer-review
Radiotherapy is a cancer treatment that applies high doses of ionizing radiation to induce cell death, mainly by triggering DNA double-strand breaks. The outcome of radiotherapy greatly depends on radiosensitivity of cancer cells, which is determined by multiple proteins and cellular processes. In this review, we summarize current knowledge on the role of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in determining the response to radiation. Non-coding RNAs modulate ionizing radiation response by targeting key signaling pathways, including DNA damage repair, apoptosis, glycolysis, cell cycle arrest, and autophagy. Additionally, we indicate miRNAs and lncRNAs that upon overexpression or inhibition alter cellular radiosensitivity. Current data indicate the potential of using specific non-coding RNAs as modulators of cellular radiosensitivity to improve outcome of radiotherapy.
|Number of pages||27|
|Publication status||Published - 23-Jun-2020|
- non-coding RNA, miRNA, lncRNA, circRNA, radiation response, radiotherapy, CELL LUNG-CANCER, NASOPHARYNGEAL CARCINOMA RADIORESISTANCE, HUMAN COLORECTAL-CANCER, STRAND BREAK REPAIR, DNA-DAMAGE RESPONSE, ENHANCES RADIOSENSITIVITY, PROSTATE-CANCER, IONIZING-RADIATION, DOWN-REGULATION, GASTRIC-CANCER