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Nocturnal non-invasive ventilation in addition to rehabilitation in hypercapnic patients with COPD

Duiverman, M. L., Wempe, J. B., Bladder, G., Jansen, D. F., Kerstjens, H. A. M., Zijlstra, J. G. & Wijkstra, P. J., Dec-2008, In : Thorax. 63, 12, p. 1052-1057 6 p.

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DOI

Background: Long-term non-invasive positive pressure ventilation (NIPPV) might improve the outcomes of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) with chronic respiratory failure. A study was undertaken to investigate whether nocturnal NIPPV in addition to pulmonary rehabilitation improves health-related quality of life, functional status and gas exchange compared with pulmonary rehabilitation alone in patients with COPD with chronic hypercapnic respiratory failure.

Methods: 72 patients with COPD were randomly assigned to nocturnal NIPPV in addition to rehabilitation (n = 37) or rehabilitation alone (n = 35). Outcome measures were assessed before and after the 3-month intervention period.

Results: The Chronic Respiratory Questionnaire total score improved 15.1 points with NIPPV + rehabilitation compared with 8.7 points with rehabilitation alone. The difference of 7.5 points was not significant (p = 0.08). However, compared with rehabilitation alone, the difference in the fatigue domain was greater with NIPPV + rehabilitation (mean difference 3.3 points, p

Conclusion: Non-invasive ventilation augments the benefits of pulmonary rehabilitation in patients with COPD with chronic hypercapnic respiratory failure as it improves several measures of health-related quality of life, functional status and gas exchange.

Original languageEnglish
Pages (from-to)1052-1057
Number of pages6
JournalThorax
Volume63
Issue number12
Publication statusPublished - Dec-2008

    Keywords

  • OBSTRUCTIVE PULMONARY-DISEASE, POSITIVE-PRESSURE VENTILATION, CHRONIC RESPIRATORY-FAILURE, QUALITY-OF-LIFE, RANDOMIZED CONTROLLED-TRIAL, CHRONIC LUNG-DISEASE, OXYGEN-THERAPY, MECHANICAL VENTILATION, STABLE COPD, EFFICACY

ID: 2699617