Publication

No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia

Ivanova, S. A., Al Hadithy, A. F. Y., Brazovskaya, N., Semke, A., Wilffert, B., Fedorenko, O., Brouwers, J. R. B. J. & Loonen, A. J. M., May-2012, In : Human Psychopharmacology. 27, 3, p. 334-337 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Svetlana A. Ivanova
  • Asmar F. Y. Al Hadithy
  • Natalia Brazovskaya
  • Arkadiy Semke
  • Bob Wilffert
  • Olga Fedorenko
  • Jacobus R. B. J. Brouwers
  • Anton J. M. Loonen

Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia. Copyright (c) 2012 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)334-337
Number of pages4
JournalHuman Psychopharmacology
Volume27
Issue number3
Publication statusPublished - May-2012

    Keywords

  • ADORA2A, dyskinesia, tardive, mechanism, adenosine A2a receptor, adult, article, clinical feature, comparative study, cross-sectional study, disease association, disease duration, female, gene frequency, genotype, hospitalization, human, incidence, major clinical study, male, mental patient, priority journal, protein polymorphism, Russian Federation, tardive dyskinesia

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