Publication

No evidence for the use of stem cell therapy for tendon disorders: a systematic review

Pas, H. I. M. F. L., Moen, M. H., Haisma, H. J. & Winters, M., Jul-2017, In : British Journal of Sports Medicine. 51, 13, p. 996-1004 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Pas, H. I. M. F. L., Moen, M. H., Haisma, H. J., & Winters, M. (2017). No evidence for the use of stem cell therapy for tendon disorders: a systematic review. British Journal of Sports Medicine, 51(13), 996-1004. https://doi.org/10.1136/bjsports-2016-096794

Author

Pas, Haiko I M F L ; Moen, Maarten H ; Haisma, Hidde J ; Winters, Marinus. / No evidence for the use of stem cell therapy for tendon disorders : a systematic review. In: British Journal of Sports Medicine. 2017 ; Vol. 51, No. 13. pp. 996-1004.

Harvard

Pas, HIMFL, Moen, MH, Haisma, HJ & Winters, M 2017, 'No evidence for the use of stem cell therapy for tendon disorders: a systematic review', British Journal of Sports Medicine, vol. 51, no. 13, pp. 996-1004. https://doi.org/10.1136/bjsports-2016-096794

Standard

No evidence for the use of stem cell therapy for tendon disorders : a systematic review. / Pas, Haiko I M F L; Moen, Maarten H; Haisma, Hidde J; Winters, Marinus.

In: British Journal of Sports Medicine, Vol. 51, No. 13, 07.2017, p. 996-1004.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Pas HIMFL, Moen MH, Haisma HJ, Winters M. No evidence for the use of stem cell therapy for tendon disorders: a systematic review. British Journal of Sports Medicine. 2017 Jul;51(13):996-1004. https://doi.org/10.1136/bjsports-2016-096794


BibTeX

@article{9a987ecc173244d798ed4f8e40240dd0,
title = "No evidence for the use of stem cell therapy for tendon disorders: a systematic review",
abstract = "INTRODUCTION: Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders.METHODS: Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search. All references of included trials were checked for possibly eligible trials. Risk of bias assessment was performed using the Cochrane risk of bias tool for controlled trials and the Newcastle-Ottawa scale for case series. Levels of evidence were assigned according to the Oxford levels of evidence.RESULTS: 4 published and three unpublished/pending trials were found with a total of 79 patients. No unpublished data were available. Two trials evaluated bone marrow-derived stem cells in rotator cuff repair surgery and found lower retear rates compared with historical controls or the literature. One trial used allogenic adipose-derived stem cells to treat lateral epicondylar tendinopathy. Improved Mayo Elbow Performance Index, Visual Analogue Pain scale and ultrasound findings after 1-year follow-up compared with baseline were found. Bone marrow-derived stem cell-treated patellar tendinopathy showed improved International Knee Documentation Committee, Knee injury and Osteoarthritis Outcome Score subscales and Tegner scores after 5-year follow-up. One trial reported adverse events and found them to be mild (eg, swelling, effusion). All trials were at high risk of bias and only level 4 evidence was available.CONCLUSIONS: No evidence (level 4) was found for the therapeutic use of stem cells for tendon disorders. The use of stem cell therapy for tendon disorders in clinical practice is currently not advised.",
author = "Pas, {Haiko I M F L} and Moen, {Maarten H} and Haisma, {Hidde J} and Marinus Winters",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.",
year = "2017",
month = "7",
doi = "10.1136/bjsports-2016-096794",
language = "English",
volume = "51",
pages = "996--1004",
journal = "British Journal of Sports Medicine",
issn = "0306-3674",
publisher = "BMJ PUBLISHING GROUP",
number = "13",

}

RIS

TY - JOUR

T1 - No evidence for the use of stem cell therapy for tendon disorders

T2 - a systematic review

AU - Pas, Haiko I M F L

AU - Moen, Maarten H

AU - Haisma, Hidde J

AU - Winters, Marinus

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

PY - 2017/7

Y1 - 2017/7

N2 - INTRODUCTION: Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders.METHODS: Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search. All references of included trials were checked for possibly eligible trials. Risk of bias assessment was performed using the Cochrane risk of bias tool for controlled trials and the Newcastle-Ottawa scale for case series. Levels of evidence were assigned according to the Oxford levels of evidence.RESULTS: 4 published and three unpublished/pending trials were found with a total of 79 patients. No unpublished data were available. Two trials evaluated bone marrow-derived stem cells in rotator cuff repair surgery and found lower retear rates compared with historical controls or the literature. One trial used allogenic adipose-derived stem cells to treat lateral epicondylar tendinopathy. Improved Mayo Elbow Performance Index, Visual Analogue Pain scale and ultrasound findings after 1-year follow-up compared with baseline were found. Bone marrow-derived stem cell-treated patellar tendinopathy showed improved International Knee Documentation Committee, Knee injury and Osteoarthritis Outcome Score subscales and Tegner scores after 5-year follow-up. One trial reported adverse events and found them to be mild (eg, swelling, effusion). All trials were at high risk of bias and only level 4 evidence was available.CONCLUSIONS: No evidence (level 4) was found for the therapeutic use of stem cells for tendon disorders. The use of stem cell therapy for tendon disorders in clinical practice is currently not advised.

AB - INTRODUCTION: Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders.METHODS: Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search. All references of included trials were checked for possibly eligible trials. Risk of bias assessment was performed using the Cochrane risk of bias tool for controlled trials and the Newcastle-Ottawa scale for case series. Levels of evidence were assigned according to the Oxford levels of evidence.RESULTS: 4 published and three unpublished/pending trials were found with a total of 79 patients. No unpublished data were available. Two trials evaluated bone marrow-derived stem cells in rotator cuff repair surgery and found lower retear rates compared with historical controls or the literature. One trial used allogenic adipose-derived stem cells to treat lateral epicondylar tendinopathy. Improved Mayo Elbow Performance Index, Visual Analogue Pain scale and ultrasound findings after 1-year follow-up compared with baseline were found. Bone marrow-derived stem cell-treated patellar tendinopathy showed improved International Knee Documentation Committee, Knee injury and Osteoarthritis Outcome Score subscales and Tegner scores after 5-year follow-up. One trial reported adverse events and found them to be mild (eg, swelling, effusion). All trials were at high risk of bias and only level 4 evidence was available.CONCLUSIONS: No evidence (level 4) was found for the therapeutic use of stem cells for tendon disorders. The use of stem cell therapy for tendon disorders in clinical practice is currently not advised.

U2 - 10.1136/bjsports-2016-096794

DO - 10.1136/bjsports-2016-096794

M3 - Article

VL - 51

SP - 996

EP - 1004

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

IS - 13

ER -

ID: 38907618