New molecular mechanisms of aging regulation

Sen, I., 2018, [Groningen]: University of Groningen. 184 p.

Research output: ThesisThesis fully internal (DIV)

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  • Title and contents

    Final publisher's version, 745 KB, PDF document

  • Chapter 1

    Final publisher's version, 1.13 MB, PDF document

  • Chapter 2

    Final publisher's version, 1.71 MB, PDF document

  • Chapter 3

    Final publisher's version, 5.14 MB, PDF document

  • Chapter 4

    Final publisher's version, 4.05 MB, PDF document

    Embargo ends: 22/10/2020

  • Chapter 5

    Final publisher's version, 721 KB, PDF document

  • Chapter 6

    Final publisher's version, 624 KB, PDF document

  • Chapter 7

    Final publisher's version, 626 KB, PDF document

  • Appendices

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  • Complete thesis

    Final publisher's version, 10.5 MB, PDF document

    Embargo ends: 22/10/2020

  • Propositions

    Final publisher's version, 116 KB, PDF document

  • Ilke Sen
Aging is a complex phenomenon, resulting from damage accumulation, the increased deregulation of biological pathways, and a loss of cellular homeostasis, all of which lead to a functional decline in the organism over time. Interestingly, aging is not a static process but it is highly regulated by an interconnected signaling network that predominantly regulates the activity of aging-preventive stress response and longevity promoting pathways. In this thesis, I provided new mechanistic insights into the transcriptional regulation of genes that promote stress resistance and longevity. For this work, I used the model organism C. elegans and focused on maybe the most central aging-regulatory signaling pathway known to date, namely insulin/IGF-like signaling (IIS) with its downstream transcription factor DAF-16/FOXO. By showing and evaluating genetic and biochemical interactions between DAF-16 and some of its essential cofactors and regulators, we gained important new insights into how DAF-16 is regulated and targets its downstream genes. Hopefully, this information provides new mechanistic avenues towards interventions against the aging process and resultant age-related diseases.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Award date22-Oct-2018
Place of Publication[Groningen]
Print ISBNs978-94-93019-85-0
Electronic ISBNs978-94-034-1115-6
Publication statusPublished - 2018

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