Publication
Never tear us a-PARP: Dealing with DNA lesions during mitosis
Schoonen, P. M. & van Vugt, M. A. T. M., 2018, In : Molecular & Cellular Oncology. 5, 1, 4 p., e1382670.Research output: Contribution to journal › Article › Academic › peer-review

Documents
- Never tear us a PARP Dealing with DNA lesions during mitosis
Final publisher's version, 1.85 MB, PDF document
DOI
Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, subsequently causing mitotic chromatin bridges, multinucleation and apoptosis. Here, we discuss the implications of these findings.
Original language | English |
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Article number | e1382670 |
Number of pages | 4 |
Journal | Molecular & Cellular Oncology |
Volume | 5 |
Issue number | 1 |
Publication status | Published - 2018 |
- Journal Article, checkpoint, olaparib, Mitosis, PARP, BRCA1/2
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