Never tear us a-PARP: Dealing with DNA lesions during mitosis

Schoonen, P. M. & van Vugt, M. A. T. M., 2018, In : Molecular & Cellular Oncology. 5, 1, 4 p., e1382670.

Research output: Contribution to journalArticleAcademicpeer-review

Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, subsequently causing mitotic chromatin bridges, multinucleation and apoptosis. Here, we discuss the implications of these findings.

Original languageEnglish
Article numbere1382670
Number of pages4
JournalMolecular & Cellular Oncology
Issue number1
Publication statusPublished - 2018


  • Journal Article, checkpoint, olaparib, Mitosis, PARP, BRCA1/2

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