Neurotrophin-3 mRNA expression in rat intrafusal muscle fibres after denervation and reinnervation

Copray, JCVM. & Brouwer, N., 24-Oct-1997, In : Neuroscience Letters. 236, 1, p. 41-44 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

We have studied the regulation of the expression of neurotrophin-3 (NT-3) mRNA in neonatal and adult rat muscle spindles after denervation and after denervation followed by reinnervation. Denervation of the intrafusal fibres did not result in an upregulation of the NT-3 mRNA expression but decreased this expression below the detection limit of the in situ hybridization method. Reinnervation of intrafusal fibres restored the NT-3 mRNA expression. The results suggest that the expression of NT-3 mRNA in postnatal muscle spindles is controlled by neuronal factors. The intrafusal fibre derived NT-3 may act as an instructive, feedback messenger for innervating neurons and may play a role in stabilizing and maintaining functional neuromuscular connections. (C) 1997 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 24-Oct-1997


  • neurotrophin-3 mRNA, muscle spindles, neurotrophic factors, proprioception, intrafusal fibres, axotomy, MOTOR-NEURON SURVIVAL, NERVE GROWTH-FACTOR, SKELETAL-MUSCLE, NEONATAL RATS, SPINDLES, MOTONEURONS

ID: 6533892