Neurotrophin-3 mRNA expression in rat intrafusal muscle fibres after denervation and reinnervationCopray, JCVM. & Brouwer, N., 24-Oct-1997, In : Neuroscience Letters. 236, 1, p. 41-44 4 p.
Research output: Contribution to journal › Article › Academic › peer-review
We have studied the regulation of the expression of neurotrophin-3 (NT-3) mRNA in neonatal and adult rat muscle spindles after denervation and after denervation followed by reinnervation. Denervation of the intrafusal fibres did not result in an upregulation of the NT-3 mRNA expression but decreased this expression below the detection limit of the in situ hybridization method. Reinnervation of intrafusal fibres restored the NT-3 mRNA expression. The results suggest that the expression of NT-3 mRNA in postnatal muscle spindles is controlled by neuronal factors. The intrafusal fibre derived NT-3 may act as an instructive, feedback messenger for innervating neurons and may play a role in stabilizing and maintaining functional neuromuscular connections. (C) 1997 Elsevier Science Ireland Ltd.
|Number of pages||4|
|Publication status||Published - 24-Oct-1997|
- neurotrophin-3 mRNA, muscle spindles, neurotrophic factors, proprioception, intrafusal fibres, axotomy, MOTOR-NEURON SURVIVAL, NERVE GROWTH-FACTOR, SKELETAL-MUSCLE, NEONATAL RATS, SPINDLES, MOTONEURONS