Publication

Neuronal chemokines: Versatile messengers in central nervous system cell interaction

de Haas, A. H., van Weering, H. R. J., de Jong, E. K., Boddeke, H. W. G. M. & Biber, K. P. H., Oct-2007, In : Molecular neurobiology. 36, 2, p. 137-151 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Whereas chemokines are well known for their ability to induce cell migration, only recently it became evident that chemokines also control a variety of other cell functions and are versatile messengers in the interaction between a diversity of cell types. In the central nervous system (CNS), chemokines are generally found under both physiological and pathological conditions. Whereas many reports describe chemokine expression in astrocytes and microglia and their role in the migration of leukocytes into the CNS, only few studies describe chemokine expression in neurons. Nevertheless, the expression of neuronal chemokines and the corresponding chemokine receptors in CNS cells under physiological and pathological conditions indicates that neuronal chemokines contribute to CNS cell interaction. In this study, we review recent studies describing neuronal chemokine expression and discuss potential roles of neuronal chemokines in neuron-astrocyte, neuron-microglia, and neuron-neuron interaction.

Original languageEnglish
Pages (from-to)137-151
Number of pages15
JournalMolecular neurobiology
Volume36
Issue number2
Publication statusPublished - Oct-2007

    Keywords

  • CNS, central nervous system, neurons, astrocytes, microglia, chemokines, cell interaction, MONOCYTE CHEMOATTRACTANT PROTEIN-1, METHYL-D-ASPARTATE, ADULT-RAT BRAIN, ISCHEMIA-REPERFUSION INJURY, CEREBELLAR GRANULE CELLS, MOUSE HIPPOCAMPAL SLICES, HUMAN FETAL ASTROCYTES, DORSAL-ROOT GANGLIA, RECEPTOR CXCR4, FUNCTIONAL EXPRESSION

ID: 4629205