Publication

Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain

Biber, K. & Boddeke, E., 7-Aug-2014, In : Frontiers in cellular neuroscience. 8, 10 p., 210.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Biber, K., & Boddeke, E. (2014). Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain. Frontiers in cellular neuroscience, 8, [210]. https://doi.org/10.3389/fncel.2014.00210

Author

Biber, Knut ; Boddeke, Erik. / Neuronal CC chemokines : the distinct roles of CCL21 and CCL2 in neuropathic pain. In: Frontiers in cellular neuroscience. 2014 ; Vol. 8.

Harvard

Biber, K & Boddeke, E 2014, 'Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain', Frontiers in cellular neuroscience, vol. 8, 210. https://doi.org/10.3389/fncel.2014.00210

Standard

Neuronal CC chemokines : the distinct roles of CCL21 and CCL2 in neuropathic pain. / Biber, Knut; Boddeke, Erik.

In: Frontiers in cellular neuroscience, Vol. 8, 210, 07.08.2014.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Biber K, Boddeke E. Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain. Frontiers in cellular neuroscience. 2014 Aug 7;8. 210. https://doi.org/10.3389/fncel.2014.00210


BibTeX

@article{8ce0cdd7e7c648e1972e5e58d8605971,
title = "Neuronal CC chemokines: the distinct roles of CCL21 and CCL2 in neuropathic pain",
abstract = "The development of neuropathic pain in response to peripheral nerve lesion for a large part depends on microglia located at the dorsal horn of the spinal cord. Thus the injured nerve initiates a response of microglia, which represents the start of a cascade of events that leads to neuropathic pain development. For long it remained obscure how a nerve injury in the periphery would initiate a microglia response in the dorsal horn of the spinal cord. Recently, two chemokines have been suggested as potential factors that mediate the communication between injured neurons and microglia namely CCL2 and CCL21. This assumption is based on the following findings. Both chemokines are not found in healthy neurons, but are expressed in response to neuronal injury. In injured dorsal root ganglion cells CCL2 and CCL21 are expressed in vesicles in the soma and transported through the axons of the dorsal root into the dorsal horn of the spinal cord. Finally, microglia in vitro are known to respond to CCL2 and CCL21. Whereas the microglial chemokine receptor involved in CCL21-induced neuropathic pain is not yet defined the situation concerning the receptors for CCL2 in microglia in vivo is even less clear. Recent results obtained in transgenic animals clearly show that microglia in vivo do not express CCR2 but that peripheral myeloid cells and neurons do. This suggests that CCL2 expressed by injured dorsal root neurons does not act as neuron-microglia signal in contrast to CCL21. Instead, CCL2 in the injured dorsal root ganglia (DRG) may act as autocrine or paracrine signal and may stimulate first or second order neurons in the pain cascade and/or attract CCR2-expressing peripheral monocytes/macrophages to the spinal cord.",
keywords = "neuropathic pain, microglia reaction, chemokines, neuron-microglia signaling, DRG neurons, LDV vesicles, regulated release pathway, PERIPHERAL-NERVE INJURY, MONOCYTE CHEMOATTRACTANT PROTEIN-1, DORSAL-ROOT GANGLION, FOCAL CEREBRAL-ISCHEMIA, SPINAL GLIAL ACTIVATION, BORNE CELL RECRUITMENT, IN-VIVO, CENTRAL SENSITIZATION, MICROGLIA ACTIVATION, MECHANICAL ALLODYNIA",
author = "Knut Biber and Erik Boddeke",
year = "2014",
month = "8",
day = "7",
doi = "10.3389/fncel.2014.00210",
language = "English",
volume = "8",
journal = "Frontiers in cellular neuroscience",
issn = "1662-5102",
publisher = "Frontiers Media SA",

}

RIS

TY - JOUR

T1 - Neuronal CC chemokines

T2 - the distinct roles of CCL21 and CCL2 in neuropathic pain

AU - Biber, Knut

AU - Boddeke, Erik

PY - 2014/8/7

Y1 - 2014/8/7

N2 - The development of neuropathic pain in response to peripheral nerve lesion for a large part depends on microglia located at the dorsal horn of the spinal cord. Thus the injured nerve initiates a response of microglia, which represents the start of a cascade of events that leads to neuropathic pain development. For long it remained obscure how a nerve injury in the periphery would initiate a microglia response in the dorsal horn of the spinal cord. Recently, two chemokines have been suggested as potential factors that mediate the communication between injured neurons and microglia namely CCL2 and CCL21. This assumption is based on the following findings. Both chemokines are not found in healthy neurons, but are expressed in response to neuronal injury. In injured dorsal root ganglion cells CCL2 and CCL21 are expressed in vesicles in the soma and transported through the axons of the dorsal root into the dorsal horn of the spinal cord. Finally, microglia in vitro are known to respond to CCL2 and CCL21. Whereas the microglial chemokine receptor involved in CCL21-induced neuropathic pain is not yet defined the situation concerning the receptors for CCL2 in microglia in vivo is even less clear. Recent results obtained in transgenic animals clearly show that microglia in vivo do not express CCR2 but that peripheral myeloid cells and neurons do. This suggests that CCL2 expressed by injured dorsal root neurons does not act as neuron-microglia signal in contrast to CCL21. Instead, CCL2 in the injured dorsal root ganglia (DRG) may act as autocrine or paracrine signal and may stimulate first or second order neurons in the pain cascade and/or attract CCR2-expressing peripheral monocytes/macrophages to the spinal cord.

AB - The development of neuropathic pain in response to peripheral nerve lesion for a large part depends on microglia located at the dorsal horn of the spinal cord. Thus the injured nerve initiates a response of microglia, which represents the start of a cascade of events that leads to neuropathic pain development. For long it remained obscure how a nerve injury in the periphery would initiate a microglia response in the dorsal horn of the spinal cord. Recently, two chemokines have been suggested as potential factors that mediate the communication between injured neurons and microglia namely CCL2 and CCL21. This assumption is based on the following findings. Both chemokines are not found in healthy neurons, but are expressed in response to neuronal injury. In injured dorsal root ganglion cells CCL2 and CCL21 are expressed in vesicles in the soma and transported through the axons of the dorsal root into the dorsal horn of the spinal cord. Finally, microglia in vitro are known to respond to CCL2 and CCL21. Whereas the microglial chemokine receptor involved in CCL21-induced neuropathic pain is not yet defined the situation concerning the receptors for CCL2 in microglia in vivo is even less clear. Recent results obtained in transgenic animals clearly show that microglia in vivo do not express CCR2 but that peripheral myeloid cells and neurons do. This suggests that CCL2 expressed by injured dorsal root neurons does not act as neuron-microglia signal in contrast to CCL21. Instead, CCL2 in the injured dorsal root ganglia (DRG) may act as autocrine or paracrine signal and may stimulate first or second order neurons in the pain cascade and/or attract CCR2-expressing peripheral monocytes/macrophages to the spinal cord.

KW - neuropathic pain

KW - microglia reaction

KW - chemokines

KW - neuron-microglia signaling

KW - DRG neurons

KW - LDV vesicles

KW - regulated release pathway

KW - PERIPHERAL-NERVE INJURY

KW - MONOCYTE CHEMOATTRACTANT PROTEIN-1

KW - DORSAL-ROOT GANGLION

KW - FOCAL CEREBRAL-ISCHEMIA

KW - SPINAL GLIAL ACTIVATION

KW - BORNE CELL RECRUITMENT

KW - IN-VIVO

KW - CENTRAL SENSITIZATION

KW - MICROGLIA ACTIVATION

KW - MECHANICAL ALLODYNIA

U2 - 10.3389/fncel.2014.00210

DO - 10.3389/fncel.2014.00210

M3 - Review article

C2 - 25147499

VL - 8

JO - Frontiers in cellular neuroscience

JF - Frontiers in cellular neuroscience

SN - 1662-5102

M1 - 210

ER -

ID: 13702580