Neuroimaging and illness progression

Frey, B. N., Minuzzi, L., Haarman, B. & Sassi, R., 11-Jun-2015, Staging and Neuroprogression in Bipolar Disorder. Kapczinski, F., Vieta, E., Magalhães, P. V. S. & Berk, M. (eds.). Oxford University Press

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

•Asymptomatic children at high-risk to develop BD have shown gray matter volume changes in several prefrontal cortical areas and reduced frontal and increased amygdala activation; Preliminary evidence suggests that development of BD may be associated with lower amygdala volumes
•Initial studies pointed to increased size of brain ventricles in patients with multiple episodes of BD
•PFC seems to be the area where reductions in grey matter are more pronounced in BD.
•Several studies replicated an increased number of WMH among adults BD patients; WMH might be a potential marker of late stages in bipolar disorder
•Functional neuroimaging studies in BD patients have shown abnormal activation involving fronto-limbic circuitry; however the usefulness of fMRI in staging/illness progression is still unknown
•Positron emission tomography molecular imaging demonstrated an increase in activated microglia in BD, supporting the theory that microglia activation plays an important role in the pathophysiology of BD.
Original languageEnglish
Title of host publicationStaging and Neuroprogression in Bipolar Disorder
EditorsFlávio Kapczinski, Eduard Vieta, Pedro V. S. Magalhães, Michael Berk
PublisherOxford University Press
ISBN (Print)9780198709992
Publication statusPublished - 11-Jun-2015

ID: 41387793