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Neurogenesis during development of the vertebrate central nervous system

Paridaen, J. T. M. L. & Huttner, W. B., 1-Apr-2014, In : Embo Reports. 15, 4, p. 351-364 14 p.

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  • Neurogenesis during development of the vertebrate central nervous system

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DOI

During vertebrate development, a wide variety of cell types and tissues emerge from a single fertilized oocyte. One of these tissues, the central nervous system, contains many types of neurons and glial cells that were born during the period of embryonic and post-natal neuro- and gliogenesis. As to neurogenesis, neural progenitors initially divide symmetrically to expand their pool and switch to asymmetric neurogenic divisions at the onset of neurogenesis. This process involves various mechanisms involving intrinsic as well as extrinsic factors. Here, we discuss the recent advances and insights into regulation of neurogenesis in the developing vertebrate central nervous system. Topics include mechanisms of (a)symmetric cell division, transcriptional and epigenetic regulation, and signaling pathways, using mostly examples from the developing mammalian neocortex.

Original languageEnglish
Pages (from-to)351-364
Number of pages14
JournalEmbo Reports
Volume15
Issue number4
Publication statusPublished - 1-Apr-2014
Externally publishedYes

    Keywords

  • Animals, Cell Differentiation, Central Nervous System, Chromosome Segregation, Epigenesis, Genetic, Gene Expression Regulation, Developmental, Humans, Mitosis, Neural Stem Cells, Neurogenesis, Signal Transduction, Spindle Apparatus, Journal Article, Research Support, Non-U.S. Gov't, Review

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