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Neurobiology of hyperactivity and reward: Agreeable restlessness in Anorexia Nervosa

Scheurink, A. J. W., Boersma, G. J., Nergardh, R., Sodersten, P., Nergårdh, R. & Södersten, P., 14-Jul-2010, In : Physiology & Behavior. 100, 5, p. 490-495 6 p.

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DOI

Restricted food intake is associated with increased physical activity, very likely an evolutionary advantage, initially both functional and rewarding. The hyperactivity of patients with Anorexia Nervosa, however, is a main problem for recovery. This seemingly paradoxical reward of hyperactivity in Anorexia Nervosa is one of the main aspects in our framework for the neurobiological changes that may underlie the development of the disorder. Here, we focus on the neurobiological basis of hyperactivity and reward in both animals and humans suggesting that the mesolimbic dopamine and hypothalamic orexin neurons play central roles.

The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. (C) 2010 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)490-495
Number of pages6
JournalPhysiology & Behavior
Volume100
Issue number5
Publication statusPublished - 14-Jul-2010
Event17th Annual Meeting of the Society-for-the-Study-of-Ingestive-Behavior -
Duration: 28-Jul-20091-Aug-2009

Event

17th Annual Meeting of the Society-for-the-Study-of-Ingestive-Behavior

28/07/200901/08/2009

Event: Other

    Keywords

  • Dopamine, Orexin, Food anticipatory activity, Activity based anorexia, VENTRAL TEGMENTAL AREA, SELF-STARVATION, FOOD-INTAKE, CIRCADIAN-RHYTHMS, PHYSICAL-ACTIVITY, FEEDING-BEHAVIOR, EATING-DISORDERS, ACTIVITY WHEELS, OREXIN NEURONS, RUNNING-WHEEL

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