Neurobiological determinants of depressive-like symptoms in rodents: A multifactorial approach

Bove, M., 2018, [Groningen]: University of Groningen. 150 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Maria Bove
Depression is one of the most common psychiatric diseases; indeed the prevalence of depressive symptoms has reached epidemic proportions during the last few decades.
Depression core symptoms include depressed mood, anhedonia (reduced ability to experience pleasure from natural rewards), irritability, difficulties in concentrating, social withdrawal (withdrawal from social contact that derives from indifference or lack of desire to have social contact) and abnormalities in appetite and sleep, the so called “neurovegetative symptoms”.
Depression has shown to be comorbid with several neuropsychiatric diseases, such as schizophrenia, bipolar disorders, Alzheimer’s diseases, anxiety disorders, autism spectrum disorders and stress-related diseases. Moreover, depression often occurs during the prodromic phase of Alzheimer’s disease, schizophrenia and bipolar disorders.
In order to study the onset and progression of mental illnesses, environmental factors, such as diets and lifestyle, and genetic factors need to be taken into account.
During the last decades, diagnosis in psychiatry only focused on subjective symptoms and observable signs. Although symptoms are an important starting point, genetics and neurobiology underlying these symptoms need to be deeply investigated. To achieve this purpose, animal models can be really helpful to longitudinally study behavioural alterations resembling human symptoms, and ultimately investigate the underlying neurobiology in order to unravel the etiopathogenesis. Therefore, in this thesis, we focused on depressive-like symptoms that occur in several neuropsychiatric and neurodegenerative diseases, and, using different animal paradigms and models, we tried to disentangle the neurobiological determinants behind these symptoms.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Kas, Martien, Supervisor
  • Cuomo, Vincenzo, Supervisor, External person
  • Zee, van der, Eddy, Assessment committee
  • Dijk, van, Gertjan, Assessment committee
  • Sortino, M. A., Assessment committee, External person
  • Steardo, L., Assessment committee, External person
Award date9-Feb-2018
Place of Publication[Groningen]
Print ISBNs978-94-6299-866-7
Electronic ISBNs978-94-6299-868-1
Publication statusPublished - 2018

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