Publication

Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder

Akkermans, S. E. A., van Rooij, D., Naaijen, J., Forde, N. J., Boecker-Schlier, R., Openneer, T. J. C., Dietric, A., Hoekstra, P. J. & Buitelaar, J. K., 30-Oct-2019, In : Psychiatry research-Neuroimaging. 292, p. 13-22 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Akkermans, S. E. A., van Rooij, D., Naaijen, J., Forde, N. J., Boecker-Schlier, R., Openneer, T. J. C., ... Buitelaar, J. K. (2019). Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder. Psychiatry research-Neuroimaging, 292, 13-22. https://doi.org/10.1016/j.pscychresns.2019.08.004

Author

Akkermans, Sophie E. A. ; van Rooij, Daan ; Naaijen, Jilly ; Forde, Natalie J. ; Boecker-Schlier, Regina ; Openneer, Thaira J. C. ; Dietric, Andrea ; Hoekstra, Pieter J. ; Buitelaar, Jan K. / Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder. In: Psychiatry research-Neuroimaging. 2019 ; Vol. 292. pp. 13-22.

Harvard

Akkermans, SEA, van Rooij, D, Naaijen, J, Forde, NJ, Boecker-Schlier, R, Openneer, TJC, Dietric, A, Hoekstra, PJ & Buitelaar, JK 2019, 'Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder', Psychiatry research-Neuroimaging, vol. 292, pp. 13-22. https://doi.org/10.1016/j.pscychresns.2019.08.004

Standard

Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder. / Akkermans, Sophie E. A.; van Rooij, Daan; Naaijen, Jilly; Forde, Natalie J.; Boecker-Schlier, Regina; Openneer, Thaira J. C.; Dietric, Andrea; Hoekstra, Pieter J.; Buitelaar, Jan K.

In: Psychiatry research-Neuroimaging, Vol. 292, 30.10.2019, p. 13-22.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Akkermans SEA, van Rooij D, Naaijen J, Forde NJ, Boecker-Schlier R, Openneer TJC et al. Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder. Psychiatry research-Neuroimaging. 2019 Oct 30;292:13-22. https://doi.org/10.1016/j.pscychresns.2019.08.004


BibTeX

@article{812e0a3e857745b5a8e51737c6b39d65,
title = "Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder",
abstract = "Attention-deficit/hyperactivity disorder (ADHD) is the most common comorbidity in individuals with Tourette syndrome (TS). Yet, it is unclear to what extent TS and ADHD show overlapping or distinct neural abnormalities. ADHD has been associated with altered reward processing, but there are very few studies on reward processing in TS. This study assessed neural activation of basal ganglia and thalamus during reward anticipation and receipt in children with TS and/or ADHD. We analysed mean activations of a priori specified regions of interest during an fMRI monetary incentive delay task. Data was used from 124 children aged 8-12 years (TS n = 47, of which 29 had comorbid ADHD; ADHD n = 29; healthy controls n = 48). ADHD severity across ADHD and TS groups and healthy controls was marginally related to hypoactivation of the right nucleus accumbens during reward anticipation; this effect was not moderated by TS diagnosis. We detected no associations of neural activation with TS. The association between ADHD severity and hypoactivation of the right nucleus accumbens during reward anticipation, independent of the presence or absence of TS, is in line with the view of nucleus accumbens hypoactivation as a dimensional, neurofunctional marker of ADHD severity, transcending the boundaries of primary diagnosis.",
keywords = "Nucleus accumbens, Basal ganglia, Children, Magnetic resonance imaging, REPETITIVE BEHAVIOR, ANTICIPATION, CHILDREN, SCALE, ADHD, REINFORCEMENT, RELIABILITY, DOPAMINE, NEUROBIOLOGY, ADOLESCENTS",
author = "Akkermans, {Sophie E. A.} and {van Rooij}, Daan and Jilly Naaijen and Forde, {Natalie J.} and Regina Boecker-Schlier and Openneer, {Thaira J. C.} and Andrea Dietric and Hoekstra, {Pieter J.} and Buitelaar, {Jan K.}",
year = "2019",
month = "10",
day = "30",
doi = "10.1016/j.pscychresns.2019.08.004",
language = "English",
volume = "292",
pages = "13--22",
journal = "Psychiatry research-Neuroimaging",
issn = "0925-4927",
publisher = "ELSEVIER IRELAND LTD",

}

RIS

TY - JOUR

T1 - Neural reward processing in paediatric Tourette syndrome and/or attention-deficit/hyperactivity disorder

AU - Akkermans, Sophie E. A.

AU - van Rooij, Daan

AU - Naaijen, Jilly

AU - Forde, Natalie J.

AU - Boecker-Schlier, Regina

AU - Openneer, Thaira J. C.

AU - Dietric, Andrea

AU - Hoekstra, Pieter J.

AU - Buitelaar, Jan K.

PY - 2019/10/30

Y1 - 2019/10/30

N2 - Attention-deficit/hyperactivity disorder (ADHD) is the most common comorbidity in individuals with Tourette syndrome (TS). Yet, it is unclear to what extent TS and ADHD show overlapping or distinct neural abnormalities. ADHD has been associated with altered reward processing, but there are very few studies on reward processing in TS. This study assessed neural activation of basal ganglia and thalamus during reward anticipation and receipt in children with TS and/or ADHD. We analysed mean activations of a priori specified regions of interest during an fMRI monetary incentive delay task. Data was used from 124 children aged 8-12 years (TS n = 47, of which 29 had comorbid ADHD; ADHD n = 29; healthy controls n = 48). ADHD severity across ADHD and TS groups and healthy controls was marginally related to hypoactivation of the right nucleus accumbens during reward anticipation; this effect was not moderated by TS diagnosis. We detected no associations of neural activation with TS. The association between ADHD severity and hypoactivation of the right nucleus accumbens during reward anticipation, independent of the presence or absence of TS, is in line with the view of nucleus accumbens hypoactivation as a dimensional, neurofunctional marker of ADHD severity, transcending the boundaries of primary diagnosis.

AB - Attention-deficit/hyperactivity disorder (ADHD) is the most common comorbidity in individuals with Tourette syndrome (TS). Yet, it is unclear to what extent TS and ADHD show overlapping or distinct neural abnormalities. ADHD has been associated with altered reward processing, but there are very few studies on reward processing in TS. This study assessed neural activation of basal ganglia and thalamus during reward anticipation and receipt in children with TS and/or ADHD. We analysed mean activations of a priori specified regions of interest during an fMRI monetary incentive delay task. Data was used from 124 children aged 8-12 years (TS n = 47, of which 29 had comorbid ADHD; ADHD n = 29; healthy controls n = 48). ADHD severity across ADHD and TS groups and healthy controls was marginally related to hypoactivation of the right nucleus accumbens during reward anticipation; this effect was not moderated by TS diagnosis. We detected no associations of neural activation with TS. The association between ADHD severity and hypoactivation of the right nucleus accumbens during reward anticipation, independent of the presence or absence of TS, is in line with the view of nucleus accumbens hypoactivation as a dimensional, neurofunctional marker of ADHD severity, transcending the boundaries of primary diagnosis.

KW - Nucleus accumbens

KW - Basal ganglia

KW - Children

KW - Magnetic resonance imaging

KW - REPETITIVE BEHAVIOR

KW - ANTICIPATION

KW - CHILDREN

KW - SCALE

KW - ADHD

KW - REINFORCEMENT

KW - RELIABILITY

KW - DOPAMINE

KW - NEUROBIOLOGY

KW - ADOLESCENTS

U2 - 10.1016/j.pscychresns.2019.08.004

DO - 10.1016/j.pscychresns.2019.08.004

M3 - Article

VL - 292

SP - 13

EP - 22

JO - Psychiatry research-Neuroimaging

JF - Psychiatry research-Neuroimaging

SN - 0925-4927

ER -

ID: 98708315