Neural and genetic underpinnings of response inhibition in adolescents with attention-deficit/hyperactivity disordervan Rooij, D., 2015, [Groningen]: University of Groningen. 125 p.
Research output: Thesis › Thesis fully internal (DIV) › Academic
In the current thesis I investigate the neural and genetic underpinnings of response inhibition, in a large cohort of adolescents with ADHD, their unaffected siblings and healthy controls. Each of the four research chapters answers a separate question. In the second chapter of this thesis I investigate the neural activation patterns during response inhibition in adolescents with ADHD and their unaffected siblings. I demonstrate reduced activation in these groups in many important nodes of inhibition and attentional networks, and linking this hypoactivation to behavioural differences in task performance and ADHD phenotype. In the third chapter I describe the functional connectivity patterns underlying response inhibition, and demonstrate that adolescents with ADHD both show decreased integration of the response inhibition network, and decreased suppression of task irrelevant networks. I show that siblings show similar deficits, but also unique compensatory connectivity patterns. In the fourth and fifth chapters I show that several genetic variants from the dopamine and serotonin pathways respectively affect the neural activation patterns during response inhibition. I find that these activation patterns are predictive of task performance, and also find that these effects do not differ between the three diagnostic groups. Taken together, these findings provide new insight into the neural underpinnings of the response inhibition deficits observed in ADHD, and demonstrate how these neural correlates can explain additional variance in the ADHD phenotype above behavioral measures of response inhibition. Additionally, these findings suggest that the neural correlates of response inhibition can link genetic variants to neuropsychological performance.
|Qualification||Doctor of Philosophy|
|Place of Publication||[Groningen]|
|Publication status||Published - 2015|
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