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Nationwide Outcome of Gastrectomy with En-Bloc Partial Pancreatectomy for Gastric Cancer

Dutch Upper Gastrointestinal Canc, van der Werf, L. R., Eshuis, W. J., Draaisma, W. A., van Etten, B., Gisbertz, S. S., van der Harst, E., Liem, M. S. L., Lemmens, V. E. P. P., Wijnhoven, B. P. L., Besselink, M. G. & Henegouwen, M. I. V. B., Dec-2019, In : Journal of Gastrointestinal Surgery. 23, 12, p. 2327-2337 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Dutch Upper Gastrointestinal Canc
  • L. R. van der Werf
  • W. J. Eshuis
  • W. A. Draaisma
  • B. van Etten
  • S. S. Gisbertz
  • E. van der Harst
  • M. S. L. Liem
  • V. E. P. P. Lemmens
  • B. P. L. Wijnhoven
  • M. G. Besselink
  • M. I. van Berge Henegouwen

Background Radical gastrectomy is the cornerstone of the treatment of gastric cancer. For tumors invading the pancreas, en-bloc partial pancreatectomy may be needed for a radical resection. The aim of this study was to evaluate the outcome of gastrectomies with partial pancreatectomy for gastric cancer.

Methods Patients who underwent gastrectomy with or without partial pancreatectomy for gastric or gastro-oesophageal junction cancer between 2011 and 2015 were selected from the Dutch Upper GI Cancer Audit (DUCA). Outcomes were resection margin (pR0) and Clavien-Dindo grade >= III postoperative complications and survival. The association between partial pancreatectomy and postoperative complications was analyzed with multivariable logistic regression. Overall survival of patients with partial pancreatectomy was estimated using the Kaplan-Meier method.

Results Of 1966 patients that underwent gastrectomy, 55 patients (2.8%) underwent en-bloc partial pancreatectomy. A pR0 resection was achieved in 45 of 55 patients (82% versus 85% in the group without additional resection, P = 0.82). Clavien-Dindo grade = III complications occurred in 21 of 55 patients (38% versus 17%, P <0.001). Median overall survival [95% confidence interval] was 15 [6.8-23.2] months. For patients with and without perioperative systemic therapy, median survival was 20 [12.3-27.7] and 10 [5.7-14.3] months, and for patients with pR0 and pR1 resection, it was 20 [11.8-28.3] and 5 [2.4-7.6] months, respectively.

Conclusions Gastrectomy with partial pancreatectomy is not only associated with a pR0 resection rate of 82% but also with increased postoperative morbidity. It should only be performed if a pR0 resection is feasible.

Original languageEnglish
Pages (from-to)2327-2337
Number of pages11
JournalJournal of Gastrointestinal Surgery
Volume23
Issue number12
Publication statusPublished - Dec-2019

    Keywords

  • Partial pancreatectomy, Gastric cancer, Gastrectomy, R0 resection, Multiviceral resection, MULTIVISCERAL RESECTION, SPLENECTOMY, MORBIDITY, DISSECTION, CARCINOMA, SURVIVAL, SURGERY, TRIAL

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