Nanodiamonds and Their Applications in CellsChipaux, M., van der Laan, K. J., Hemelaar, S. R., Hasani, M., Zheng, T. & Schirhagl, R., 14-Jun-2018, In : Small. 14, 24, 25 p., 1704263.
Research output: Contribution to journal › Review article › Academic › peer-review
Diamonds owe their fame to a unique set of outstanding properties. They combine a high refractive index, hardness, great stability and inertness, and low electrical but high thermal conductivity. Diamond defects have recently attracted a lot of attention. Given this unique list of properties, it is not surprising that diamond nanoparticles are utilized for numerous applications. Due to their hardness, they are routinely used as abrasives. Their small and uniform size qualifies them as attractive carriers for drug delivery. The stable fluorescence of diamond defects allows their use as stable single photon sources or biolabels. The magnetic properties of the defects make them stable spin qubits in quantum information. This property also allows their use as a sensor for temperature, magnetic fields, electric fields, or strain. This Review focuses on applications in cells. Different diamond materials and the special requirements for the respective applications are discussed. Methods to chemically modify the surface of diamonds and the different hurdles one has to overcome when working with cells, such as entering the cells and biocompatibility, are described. Finally, the recent developments and applications in labeling, sensing, drug delivery, theranostics, antibiotics, and tissue engineering are critically discussed.
|Number of pages||25|
|Publication status||Published - 14-Jun-2018|
- cell biology, cells, nanodiamonds, NV centers, uptake in cells, NITROGEN-VACANCY CENTERS, CONJUGATED FLUORESCENT NANODIAMONDS, SINGLE DEFECT CENTERS, DIAMOND NANOPARTICLES, IN-VIVO, MAGNETIC-RESONANCE, CELLULAR UPTAKE, DRUG-DELIVERY, CANCER-CELLS, FUNCTIONALIZED NANODIAMONDS