Publication

N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming

Oosting, A., Kegler, D., Boehm, G., Jansen, H. T., van de Heijning, B. J. M. & van der Beek, E. M., Dec-2010, In : Pediatric Research. 68, 6, p. 494-9 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Oosting, A., Kegler, D., Boehm, G., Jansen, H. T., van de Heijning, B. J. M., & van der Beek, E. M. (2010). N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming. Pediatric Research, 68(6), 494-9. https://doi.org/10.1203/PDR.0b013e3181f74940

Author

Oosting, Annemarie ; Kegler, Diane ; Boehm, Günther ; Jansen, Harm T ; van de Heijning, Bert J M ; van der Beek, Eline M. / N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming. In: Pediatric Research. 2010 ; Vol. 68, No. 6. pp. 494-9.

Harvard

Oosting, A, Kegler, D, Boehm, G, Jansen, HT, van de Heijning, BJM & van der Beek, EM 2010, 'N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming', Pediatric Research, vol. 68, no. 6, pp. 494-9. https://doi.org/10.1203/PDR.0b013e3181f74940

Standard

N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming. / Oosting, Annemarie; Kegler, Diane; Boehm, Günther; Jansen, Harm T; van de Heijning, Bert J M; van der Beek, Eline M.

In: Pediatric Research, Vol. 68, No. 6, 12.2010, p. 494-9.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Oosting A, Kegler D, Boehm G, Jansen HT, van de Heijning BJM, van der Beek EM. N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming. Pediatric Research. 2010 Dec;68(6):494-9. https://doi.org/10.1203/PDR.0b013e3181f74940


BibTeX

@article{12ddc2978ca14f39bb8feab4ec870df8,
title = "N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming",
abstract = "This study investigates whether improved quality of nutrients during early postnatal life has effects on adult metabolic profile and body composition in a murine model of nutritional programming. Male offspring of C57Bl/6j dams received a diet containing 21{\%} energy (En{\%}) as fat of either 100{\%} vegetable oils [control (CTRL)] or 80{\%} vegetable oils/20{\%} tuna fish oil [rich in n-3 long-chain polyunsaturated fatty acids (n-3 LCP)] from postnatal day (PN) 2 to 42. Subsequently, mice of both experimental groups were switched to a western style diet (WSD; 21 En{\%} fat, high saturated fatty acid [FA] content, and cholesterol) until dissection at PN98. Body composition was analyzed by dual x-ray absorptiometry during the WSD challenge. Results showed that a n-3 LCP-rich diet during postnatal life not only reduced fat accumulation by ∼30{\%} during the WSD challenge from PN42 to 98 (p < 0.001) but also led to a healthier plasma lipid profile, healthier plasma glucose homeostasis, and less hypertrophic adipocytes compared with CTRL. This study shows that postnatal nutrition has programming effects on adult body composition and metabolic homeostasis. In addition, it emphasizes that moderate alterations in fat quality during early postnatal life considerably affect adult metabolic health.",
keywords = "Absorptiometry, Photon, Adipose Tissue/anatomy & histology, Adult, Animals, Body Composition, Dietary Fats, Unsaturated, Fatty Acids, Omega-3/chemistry, Female, Humans, Male, Mice, Mice, Inbred C57BL, Nutritional Status",
author = "Annemarie Oosting and Diane Kegler and G{\"u}nther Boehm and Jansen, {Harm T} and {van de Heijning}, {Bert J M} and {van der Beek}, {Eline M}",
year = "2010",
month = "12",
doi = "10.1203/PDR.0b013e3181f74940",
language = "English",
volume = "68",
pages = "494--9",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - N-3 long-chain polyunsaturated fatty acids prevent excessive fat deposition in adulthood in a mouse model of postnatal nutritional programming

AU - Oosting, Annemarie

AU - Kegler, Diane

AU - Boehm, Günther

AU - Jansen, Harm T

AU - van de Heijning, Bert J M

AU - van der Beek, Eline M

PY - 2010/12

Y1 - 2010/12

N2 - This study investigates whether improved quality of nutrients during early postnatal life has effects on adult metabolic profile and body composition in a murine model of nutritional programming. Male offspring of C57Bl/6j dams received a diet containing 21% energy (En%) as fat of either 100% vegetable oils [control (CTRL)] or 80% vegetable oils/20% tuna fish oil [rich in n-3 long-chain polyunsaturated fatty acids (n-3 LCP)] from postnatal day (PN) 2 to 42. Subsequently, mice of both experimental groups were switched to a western style diet (WSD; 21 En% fat, high saturated fatty acid [FA] content, and cholesterol) until dissection at PN98. Body composition was analyzed by dual x-ray absorptiometry during the WSD challenge. Results showed that a n-3 LCP-rich diet during postnatal life not only reduced fat accumulation by ∼30% during the WSD challenge from PN42 to 98 (p < 0.001) but also led to a healthier plasma lipid profile, healthier plasma glucose homeostasis, and less hypertrophic adipocytes compared with CTRL. This study shows that postnatal nutrition has programming effects on adult body composition and metabolic homeostasis. In addition, it emphasizes that moderate alterations in fat quality during early postnatal life considerably affect adult metabolic health.

AB - This study investigates whether improved quality of nutrients during early postnatal life has effects on adult metabolic profile and body composition in a murine model of nutritional programming. Male offspring of C57Bl/6j dams received a diet containing 21% energy (En%) as fat of either 100% vegetable oils [control (CTRL)] or 80% vegetable oils/20% tuna fish oil [rich in n-3 long-chain polyunsaturated fatty acids (n-3 LCP)] from postnatal day (PN) 2 to 42. Subsequently, mice of both experimental groups were switched to a western style diet (WSD; 21 En% fat, high saturated fatty acid [FA] content, and cholesterol) until dissection at PN98. Body composition was analyzed by dual x-ray absorptiometry during the WSD challenge. Results showed that a n-3 LCP-rich diet during postnatal life not only reduced fat accumulation by ∼30% during the WSD challenge from PN42 to 98 (p < 0.001) but also led to a healthier plasma lipid profile, healthier plasma glucose homeostasis, and less hypertrophic adipocytes compared with CTRL. This study shows that postnatal nutrition has programming effects on adult body composition and metabolic homeostasis. In addition, it emphasizes that moderate alterations in fat quality during early postnatal life considerably affect adult metabolic health.

KW - Absorptiometry, Photon

KW - Adipose Tissue/anatomy & histology

KW - Adult

KW - Animals

KW - Body Composition

KW - Dietary Fats, Unsaturated

KW - Fatty Acids, Omega-3/chemistry

KW - Female

KW - Humans

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Nutritional Status

U2 - 10.1203/PDR.0b013e3181f74940

DO - 10.1203/PDR.0b013e3181f74940

M3 - Article

C2 - 20724957

VL - 68

SP - 494

EP - 499

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 6

ER -

ID: 119138103