Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic: prevalence, predictors and relation with vitamin D

Riphagen, I. J., van der Veer, E., Muskiet, F. A. J. & DeJongste, M. J. L., Jul-2012, In : Current Medical Research and Opinion. 28, 7, p. 1247-1252 6 p.

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  • Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic

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The mechanism of statin-related myopathy is unknown, while its prevalence is probably underestimated. An association between statin-related myopathy and vitamin D deficiency has been reported. In this pilot study we assessed the prevalence of myopathy in statin users attending the outpatient clinic of the Department of Cardiology of a University Hospital from October 2009 to March 2010. We also searched for predictors of myopathy and investigated whether the myopathy was associated with vitamin D deficiency.

Research design and methods:

Statin-treated patients were asked to complete an assisted structured questionnaire. Serum creatine kinase (CK) and 25-hydroxyvitamin D (25(OH) D) were measured. Patients with rheumatic diseases, muscle diseases, (poly) neuropathy and peripheral arterial disease were excluded from predictor analysis.

Main outcome measures:

Percentage of patients with myopathy in the daily clinical practice of an outpatient clinic, serum 25(OH) D, CK, and predictors of myopathy.


One hundred and four statin-treated patients completed the questionnaire. Serum 25(OH) D was measured in 93 patients. Twenty patients with confounding comorbidities were excluded from analysis. Of the remaining 84 patients, 33% reported myopathy, 24% had myalgia and 6% myositis. Rhabdomyolysis was not observed. Time spent outdoors during winter (= 1/week; 0.19; 0.04-0.89) were predictors of myopathy in multivariate analysis.


Considering the small patient group and a relatively narrow range of vitamin D levels, we arrive at the following statements: 1) one out of three patients reported myopathy; 2) BMI, CK, number of prescription drugs, time spent outdoors and fish consumption were myopathy predictors; and 3) myopathy and 25(OH) D were unrelated.

Original languageEnglish
Pages (from-to)1247-1252
Number of pages6
JournalCurrent Medical Research and Opinion
Issue number7
Publication statusPublished - Jul-2012


  • 25-hydroxyvitamin D, HMG-CoA reductase inhibitors, Myopathy predictors, Myopathy prevalence, Statins, Vitamin D, C-REACTIVE PROTEIN, MYOSITIS-MYALGIA, D DEFICIENCY, RISK, 25-HYDROXYVITAMIN-D, INFLAMMATION, MARKERS, HEALTH, TISSUE, WOMEN

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