Publication

Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease

van der Veen, B. S., de Winther, M. P. J. & Heeringa, P., Nov-2009, In : Antioxidants & Redox Signaling. 11, 11, p. 2899-2937 39 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

van der Veen, B. S., de Winther, M. P. J., & Heeringa, P. (2009). Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease. Antioxidants & Redox Signaling, 11(11), 2899-2937. https://doi.org/10.1089/ars.2009.2538

Author

van der Veen, Betty S. ; de Winther, Menno P. J. ; Heeringa, Peter. / Myeloperoxidase : Molecular Mechanisms of Action and Their Relevance to Human Health and Disease. In: Antioxidants & Redox Signaling. 2009 ; Vol. 11, No. 11. pp. 2899-2937.

Harvard

van der Veen, BS, de Winther, MPJ & Heeringa, P 2009, 'Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease', Antioxidants & Redox Signaling, vol. 11, no. 11, pp. 2899-2937. https://doi.org/10.1089/ars.2009.2538

Standard

Myeloperoxidase : Molecular Mechanisms of Action and Their Relevance to Human Health and Disease. / van der Veen, Betty S.; de Winther, Menno P. J.; Heeringa, Peter.

In: Antioxidants & Redox Signaling, Vol. 11, No. 11, 11.2009, p. 2899-2937.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

van der Veen BS, de Winther MPJ, Heeringa P. Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease. Antioxidants & Redox Signaling. 2009 Nov;11(11):2899-2937. https://doi.org/10.1089/ars.2009.2538


BibTeX

@article{b1d75187e1aa4f75976d02b361adca25,
title = "Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease",
abstract = "Myeloperoxidase (MPO) is a heme-containing peroxidase abundantly expressed in neutrophils and to a lesser extent in monocytes. Enzymatically active MPO, together with hydrogen peroxide and chloride, produces the powerful oxidant hypochlorous acid and is a key contributor to the oxygen-dependent microbicidal activity of phagocytes. In addition, excessive generation of MPO-derived oxidants has been linked to tissue damage in many diseases, especially those characterized by acute or chronic inflammation. It has become increasingly clear that MPO exerts effects that are beyond its oxidative properties. These properties of MPO are, in many cases, independent of its catalytic activity and affect various processes involved in cell signaling and cell-cell interactions and are, as such, capable of modulating inflammatory responses. Given these diverse effects, an increased interest has emerged in the role of MPO and its downstream products in a wide range of inflammatory diseases. In this article, our knowledge pertaining to the biologic role of MPO and its downstream effects and mechanisms of action in health and disease is reviewed and discussed. Antioxid. Redox Signal. 11, 2899-2937.",
keywords = "ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES, LUNG-CANCER RISK, CORONARY-ARTERY-DISEASE, LOW-DENSITY-LIPOPROTEIN, NITRIC-OXIDE SYNTHASE, HYPOCHLORITE-MODIFIED PROTEINS, HUMAN ATHEROSCLEROTIC LESIONS, INFLAMMATORY-BOWEL-DISEASE, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, ASSOCIATION IMPLICATES MYELOPEROXIDASE",
author = "{van der Veen}, {Betty S.} and {de Winther}, {Menno P. J.} and Peter Heeringa",
year = "2009",
month = "11",
doi = "10.1089/ars.2009.2538",
language = "English",
volume = "11",
pages = "2899--2937",
journal = "Antioxidants & Redox Signaling",
issn = "1523-0864",
publisher = "MARY ANN LIEBERT, INC",
number = "11",

}

RIS

TY - JOUR

T1 - Myeloperoxidase

T2 - Molecular Mechanisms of Action and Their Relevance to Human Health and Disease

AU - van der Veen, Betty S.

AU - de Winther, Menno P. J.

AU - Heeringa, Peter

PY - 2009/11

Y1 - 2009/11

N2 - Myeloperoxidase (MPO) is a heme-containing peroxidase abundantly expressed in neutrophils and to a lesser extent in monocytes. Enzymatically active MPO, together with hydrogen peroxide and chloride, produces the powerful oxidant hypochlorous acid and is a key contributor to the oxygen-dependent microbicidal activity of phagocytes. In addition, excessive generation of MPO-derived oxidants has been linked to tissue damage in many diseases, especially those characterized by acute or chronic inflammation. It has become increasingly clear that MPO exerts effects that are beyond its oxidative properties. These properties of MPO are, in many cases, independent of its catalytic activity and affect various processes involved in cell signaling and cell-cell interactions and are, as such, capable of modulating inflammatory responses. Given these diverse effects, an increased interest has emerged in the role of MPO and its downstream products in a wide range of inflammatory diseases. In this article, our knowledge pertaining to the biologic role of MPO and its downstream effects and mechanisms of action in health and disease is reviewed and discussed. Antioxid. Redox Signal. 11, 2899-2937.

AB - Myeloperoxidase (MPO) is a heme-containing peroxidase abundantly expressed in neutrophils and to a lesser extent in monocytes. Enzymatically active MPO, together with hydrogen peroxide and chloride, produces the powerful oxidant hypochlorous acid and is a key contributor to the oxygen-dependent microbicidal activity of phagocytes. In addition, excessive generation of MPO-derived oxidants has been linked to tissue damage in many diseases, especially those characterized by acute or chronic inflammation. It has become increasingly clear that MPO exerts effects that are beyond its oxidative properties. These properties of MPO are, in many cases, independent of its catalytic activity and affect various processes involved in cell signaling and cell-cell interactions and are, as such, capable of modulating inflammatory responses. Given these diverse effects, an increased interest has emerged in the role of MPO and its downstream products in a wide range of inflammatory diseases. In this article, our knowledge pertaining to the biologic role of MPO and its downstream effects and mechanisms of action in health and disease is reviewed and discussed. Antioxid. Redox Signal. 11, 2899-2937.

KW - ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES

KW - LUNG-CANCER RISK

KW - CORONARY-ARTERY-DISEASE

KW - LOW-DENSITY-LIPOPROTEIN

KW - NITRIC-OXIDE SYNTHASE

KW - HYPOCHLORITE-MODIFIED PROTEINS

KW - HUMAN ATHEROSCLEROTIC LESIONS

KW - INFLAMMATORY-BOWEL-DISEASE

KW - EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

KW - ASSOCIATION IMPLICATES MYELOPEROXIDASE

U2 - 10.1089/ars.2009.2538

DO - 10.1089/ars.2009.2538

M3 - Review article

VL - 11

SP - 2899

EP - 2937

JO - Antioxidants & Redox Signaling

JF - Antioxidants & Redox Signaling

SN - 1523-0864

IS - 11

ER -

ID: 4970259