Publication

Myeloid cells regulate plasma LDL-cholesterol levels

Bazioti, V., La Rose, A. M. & Westerterp, M., Jun-2018, In : Current Opinion in Lipidology. 29, 3, p. 233-239 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Copy link to clipboard

Documents

  • Myeloid cells regulate plasma LDL-cholesterol levels

    Final publisher's version, 336 KB, PDF-document

DOI

Purpose of review

Leukocytosis, elevated blood leukocyte levels, is associated with enhanced cardiovascular risk in humans. Hematopoietic stem and progenitor cells (HSPCs) drive leukocyte production in a process called hematopoiesis, which mainly occurs in the bone marrow, and under certain conditions also in other organs such as the spleen. Cholesterol accumulation in HSPCs enhances hematopoiesis, increasing levels of blood monocytes that infiltrate into atherosclerotic plaques. Although HSPC proliferation and monocytosis enhance atherogenesis in several studies, concomitant decreases in LDL-cholesterol levels have also been reported, associated with anti-atherogenic effects. This review focuses on the link between HSPC proliferation, leukocytosis, plasma LDL-cholesterol levels, and atherogenesis.

Recent findings

Recent studies have shown that an acute infection enhances cholesterol accumulation in HSPCs, driving HSPC proliferation, and leading to the expansion of myeloid cells (monocytes, neutrophils, and macrophages). Enhanced hematopoiesis is associated with low plasma LDL-cholesterol levels in animal models and humans, probably because of the increased number of myeloid cells that take up LDL-cholesterol. Despite low-plasma LDL-cholesterol levels, specific patient populations with enhanced hematopoiesis show increased cardiovascular risk.

Summary

Enhanced hematopoiesis and monocytosis may accelerate atherogenesis. Studies on these processes may lead to the identification of new therapeutic targets for cardiovascular diseases.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalCurrent Opinion in Lipidology
Volume29
Issue number3
Publication statusPublished - Jun-2018

    Keywords

  • atherosclerosis, hematopoiesis, inflammation, LDL-cholesterol, leukocytosis, COLONY-STIMULATING FACTOR, LOW-DENSITY-LIPOPROTEIN, BINDING CASSETTE TRANSPORTERS, RECEPTOR KNOCKOUT MICE, TYROSINE KINASE JAK2, MYELOPROLIFERATIVE DISORDERS, ACCELERATES ATHEROSCLEROSIS, LIPID-ACCUMULATION, POLYCYTHEMIA-VERA, COMBINED DELETION

View graph of relations

ID: 61156193