Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Wyss, A. B., Sofer, T., Lee, M. K., Terzikhan, N., Nguyen, J. N., Lahousse, L., Latourelle, J. C., Smith, A. V., Bartz, T. M., Feitosa, M. F., Gao, W., Ahluwalia, T. S., Tang, W., Oldmeadow, C., Duan, Q., de Jong, K., Wojczynski, M. K., Wang, X-Q., Noordam, R., Hartwig, F. P., Jackson, V. E., Wang, T., Obeidat, M., Hobbs, B. D., Huan, T., Gui, H., Parker, M. M., Hu, D., Mogil, L. S., Kichaev, G., Jin, J., Graff, M., Harris, T. B., Kalhan, R., Heckbert, S. R., Paternoster, L., Burkart, K. M., Liu, Y., Holliday, E. G., Wilson, J. G., Vonk, J. M., Sanders, J. L., Barr, R. G., de Mutsert, R., Menezes, A. M. B., Adams, H. H. H., van den Berge, M., Joehanes, R., Levin, A. M. & Boezen, H. M., 30-Jul-2018, In : Nature Communications. 9, 1, 15 p., 2976.

Research output: Contribution to journalArticleAcademicpeer-review

  • Annah B Wyss
  • Tamar Sofer
  • Mi Kyeong Lee
  • Natalie Terzikhan
  • Jennifer N Nguyen
  • Lies Lahousse
  • Jeanne C Latourelle
  • Albert Vernon Smith
  • Traci M Bartz
  • Mary F Feitosa
  • Wei Gao
  • Tarunveer S Ahluwalia
  • Wenbo Tang
  • Christopher Oldmeadow
  • Qing Duan
  • Kim de Jong
  • Mary K Wojczynski
  • Xin-Qun Wang
  • Raymond Noordam
  • Fernando Pires Hartwig
  • Victoria E Jackson
  • Tianyuan Wang
  • Ma'en Obeidat
  • Brian D Hobbs
  • Tianxiao Huan
  • Hongsheng Gui
  • Margaret M Parker
  • Donglei Hu
  • Lauren S Mogil
  • Gleb Kichaev
  • Jianping Jin
  • Mariaelisa Graff
  • Tamara B Harris
  • Ravi Kalhan
  • Susan R Heckbert
  • Lavinia Paternoster
  • Kristin M Burkart
  • Yongmei Liu
  • Elizabeth G Holliday
  • James G Wilson
  • Judith M Vonk
  • Jason L Sanders
  • R Graham Barr
  • Renée de Mutsert
  • Ana Maria Baptista Menezes
  • Hieab H H Adams
  • Maarten van den Berge
  • Roby Joehanes
  • Albert M Levin
  • H Marike Boezen

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci.

Original languageEnglish
Article number2976
Number of pages15
JournalNature Communications
Issue number1
Publication statusPublished - 30-Jul-2018

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