Publication

Multidrug-Resistant Infections Among Hospitalized Adults With Community-Acquired Pneumonia In An Indonesian Tertiary Referral Hospital

Purba, A., Ascobat, P., Muchtar, A., Wulandari, L., Rosyid, A. N., Purwono, P. B., van der Werf, T. S., Friedrich, A. W. & Postma, M., 25-Nov-2019, In : Infection and Drug Resistance. 2019, 12, p. 3663-3675 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Purba, A., Ascobat, P., Muchtar, A., Wulandari, L., Rosyid, A. N., Purwono, P. B., van der Werf, T. S., Friedrich, A. W., & Postma, M. (2019). Multidrug-Resistant Infections Among Hospitalized Adults With Community-Acquired Pneumonia In An Indonesian Tertiary Referral Hospital. Infection and Drug Resistance, 2019(12), 3663-3675. https://doi.org/10.2147/IDR.S217842

Author

Purba, Abdul ; Ascobat, Purwantyastuti ; Muchtar, Armen ; Wulandari, Laksmi ; Rosyid, Alfian Nur ; Purwono, Priyo Budi ; van der Werf, Tjip S. ; Friedrich, A. W. ; Postma, Maarten. / Multidrug-Resistant Infections Among Hospitalized Adults With Community-Acquired Pneumonia In An Indonesian Tertiary Referral Hospital. In: Infection and Drug Resistance. 2019 ; Vol. 2019, No. 12. pp. 3663-3675.

Harvard

Purba, A, Ascobat, P, Muchtar, A, Wulandari, L, Rosyid, AN, Purwono, PB, van der Werf, TS, Friedrich, AW & Postma, M 2019, 'Multidrug-Resistant Infections Among Hospitalized Adults With Community-Acquired Pneumonia In An Indonesian Tertiary Referral Hospital', Infection and Drug Resistance, vol. 2019, no. 12, pp. 3663-3675. https://doi.org/10.2147/IDR.S217842

Standard

Multidrug-Resistant Infections Among Hospitalized Adults With Community-Acquired Pneumonia In An Indonesian Tertiary Referral Hospital. / Purba, Abdul; Ascobat, Purwantyastuti ; Muchtar, Armen ; Wulandari, Laksmi ; Rosyid, Alfian Nur ; Purwono, Priyo Budi ; van der Werf, Tjip S. ; Friedrich, A. W.; Postma, Maarten.

In: Infection and Drug Resistance, Vol. 2019, No. 12, 25.11.2019, p. 3663-3675.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Purba A, Ascobat P, Muchtar A, Wulandari L, Rosyid AN, Purwono PB et al. Multidrug-Resistant Infections Among Hospitalized Adults With Community-Acquired Pneumonia In An Indonesian Tertiary Referral Hospital. Infection and Drug Resistance. 2019 Nov 25;2019(12):3663-3675. https://doi.org/10.2147/IDR.S217842


BibTeX

@article{424c1cfce11c488d96dccc34b53de4bc,
title = "Multidrug-Resistant Infections Among Hospitalized Adults With Community-Acquired Pneumonia In An Indonesian Tertiary Referral Hospital",
abstract = "Objectives: To evaluate the clinical and microbiological appearance among hospitalized pneumonia patients focusing on resistance and risk factors for mortality in a referral hospital.Patients and methods: The study was an observational retrospective study on patients with CAP from 2014 to 2016 at Dr Soetomo referral hospital of Surabaya, Indonesia. All positive cultures with antimicrobial susceptibility results from blood and respiratory specimens were included. Patients infected with drug-susceptible pathogens and MDR organisms were also assessed in terms of clinical characteristics, day-3 clinical improvement, and 14-day mortality.Results: Of 202 isolates, 181 possessed antimicrobial susceptibility data. S. pneumoniae was the most prevalent pathogen causing CAP (18.3%). Most patients were empirically treated with ceftriaxone (n=75; 41.4%). Among beta-lactam antibiotics, the susceptibility to the third-generation cephalosporins remained relatively high, between 67.4% and 82.3%, compared with the other beta-lactams such as amoxicillin/clavulanate and ampicillin/sulbactam (a sensitivity rate of 36.5% and 47.5, respectively). For carbapenem antibiotics, imipenem and meropenem susceptibility was 69.6% and 82.3% respectively. Approximately 22% of isolates were identified as MDR that showed significant differences in clinical outcomes of 14-day mortality rates (p<0.001). Notably, patients with day-3 improvement had a lower risk of mortality (OR= 0.06; 95% CI= 0.02-0.19).Conclusion: One-fifth of causative agents among hospitalized CAP cases were identified as MDR organisms. The pathogens of MDR and non-MDR CAP remain susceptible to the third-generation cephalosporins. Together with additional consideration of culture findings and Pneumonia Severity Index (PSI) assessment, a 3-day clinical assessment is essential to predict the prognosis of 14-day mortality.",
author = "Abdul Purba and Purwantyastuti Ascobat and Armen Muchtar and Laksmi Wulandari and Rosyid, {Alfian Nur} and Purwono, {Priyo Budi} and {van der Werf}, {Tjip S.} and Friedrich, {A. W.} and Maarten Postma",
note = "{\textcopyright} 2019 Purba et al.",
year = "2019",
month = nov,
day = "25",
doi = "10.2147/IDR.S217842",
language = "English",
volume = "2019",
pages = "3663--3675",
journal = "Infection and Drug Resistance",
issn = "1178-6973",
publisher = "DOVE MEDICAL PRESS LTD",
number = "12",

}

RIS

TY - JOUR

T1 - Multidrug-Resistant Infections Among Hospitalized Adults With Community-Acquired Pneumonia In An Indonesian Tertiary Referral Hospital

AU - Purba, Abdul

AU - Ascobat, Purwantyastuti

AU - Muchtar, Armen

AU - Wulandari, Laksmi

AU - Rosyid, Alfian Nur

AU - Purwono, Priyo Budi

AU - van der Werf, Tjip S.

AU - Friedrich, A. W.

AU - Postma, Maarten

N1 - © 2019 Purba et al.

PY - 2019/11/25

Y1 - 2019/11/25

N2 - Objectives: To evaluate the clinical and microbiological appearance among hospitalized pneumonia patients focusing on resistance and risk factors for mortality in a referral hospital.Patients and methods: The study was an observational retrospective study on patients with CAP from 2014 to 2016 at Dr Soetomo referral hospital of Surabaya, Indonesia. All positive cultures with antimicrobial susceptibility results from blood and respiratory specimens were included. Patients infected with drug-susceptible pathogens and MDR organisms were also assessed in terms of clinical characteristics, day-3 clinical improvement, and 14-day mortality.Results: Of 202 isolates, 181 possessed antimicrobial susceptibility data. S. pneumoniae was the most prevalent pathogen causing CAP (18.3%). Most patients were empirically treated with ceftriaxone (n=75; 41.4%). Among beta-lactam antibiotics, the susceptibility to the third-generation cephalosporins remained relatively high, between 67.4% and 82.3%, compared with the other beta-lactams such as amoxicillin/clavulanate and ampicillin/sulbactam (a sensitivity rate of 36.5% and 47.5, respectively). For carbapenem antibiotics, imipenem and meropenem susceptibility was 69.6% and 82.3% respectively. Approximately 22% of isolates were identified as MDR that showed significant differences in clinical outcomes of 14-day mortality rates (p<0.001). Notably, patients with day-3 improvement had a lower risk of mortality (OR= 0.06; 95% CI= 0.02-0.19).Conclusion: One-fifth of causative agents among hospitalized CAP cases were identified as MDR organisms. The pathogens of MDR and non-MDR CAP remain susceptible to the third-generation cephalosporins. Together with additional consideration of culture findings and Pneumonia Severity Index (PSI) assessment, a 3-day clinical assessment is essential to predict the prognosis of 14-day mortality.

AB - Objectives: To evaluate the clinical and microbiological appearance among hospitalized pneumonia patients focusing on resistance and risk factors for mortality in a referral hospital.Patients and methods: The study was an observational retrospective study on patients with CAP from 2014 to 2016 at Dr Soetomo referral hospital of Surabaya, Indonesia. All positive cultures with antimicrobial susceptibility results from blood and respiratory specimens were included. Patients infected with drug-susceptible pathogens and MDR organisms were also assessed in terms of clinical characteristics, day-3 clinical improvement, and 14-day mortality.Results: Of 202 isolates, 181 possessed antimicrobial susceptibility data. S. pneumoniae was the most prevalent pathogen causing CAP (18.3%). Most patients were empirically treated with ceftriaxone (n=75; 41.4%). Among beta-lactam antibiotics, the susceptibility to the third-generation cephalosporins remained relatively high, between 67.4% and 82.3%, compared with the other beta-lactams such as amoxicillin/clavulanate and ampicillin/sulbactam (a sensitivity rate of 36.5% and 47.5, respectively). For carbapenem antibiotics, imipenem and meropenem susceptibility was 69.6% and 82.3% respectively. Approximately 22% of isolates were identified as MDR that showed significant differences in clinical outcomes of 14-day mortality rates (p<0.001). Notably, patients with day-3 improvement had a lower risk of mortality (OR= 0.06; 95% CI= 0.02-0.19).Conclusion: One-fifth of causative agents among hospitalized CAP cases were identified as MDR organisms. The pathogens of MDR and non-MDR CAP remain susceptible to the third-generation cephalosporins. Together with additional consideration of culture findings and Pneumonia Severity Index (PSI) assessment, a 3-day clinical assessment is essential to predict the prognosis of 14-day mortality.

U2 - 10.2147/IDR.S217842

DO - 10.2147/IDR.S217842

M3 - Article

C2 - 31819549

VL - 2019

SP - 3663

EP - 3675

JO - Infection and Drug Resistance

JF - Infection and Drug Resistance

SN - 1178-6973

IS - 12

ER -

ID: 107571434