Publication

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Soc Sci Grp & Lifelines Cohort, Apr-2019, In : Nature Genetics. 51, 4, p. 636-+ 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Soc Sci Grp, & Lifelines Cohort (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51(4), 636-+. https://doi.org/10.1038/s41588-019-0378-y

Author

COGENT-Kidney Consortium ; EPIC-InterAct Consortium ; Understanding Soc Sci Grp ; Lifelines Cohort. / Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. In: Nature Genetics. 2019 ; Vol. 51, No. 4. pp. 636-+.

Harvard

COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Soc Sci Grp & Lifelines Cohort 2019, 'Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids' Nature Genetics, vol. 51, no. 4, pp. 636-+. https://doi.org/10.1038/s41588-019-0378-y

Standard

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. / COGENT-Kidney Consortium; EPIC-InterAct Consortium; Understanding Soc Sci Grp; Lifelines Cohort.

In: Nature Genetics, Vol. 51, No. 4, 04.2019, p. 636-+.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Soc Sci Grp, Lifelines Cohort. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics. 2019 Apr;51(4):636-+. https://doi.org/10.1038/s41588-019-0378-y


BibTeX

@article{2dc52ee33eea45279026c0cd1362669a,
title = "Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids",
abstract = "The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.",
keywords = "ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, NICOTINE METABOLISM, RISK LOCI, METAANALYSIS, ARCHITECTURE, CHOLESTEROL, CIGARETTES, VARIANTS, SUSCEPTIBILITY",
author = "{COGENT-Kidney Consortium} and {EPIC-InterAct Consortium} and {Understanding Soc Sci Grp} and {Lifelines Cohort} and Bentley, {Amy R.} and Sung, {Yun J.} and Brown, {Michael R.} and Winkler, {Thomas W.} and Kraja, {Aldi T.} and Ioanna Ntalla and Karen Schwander and Daniel Chasman and Elise Lim and Xuan Deng and Xiuqing Guo and Jingmin Liu and Yingchang Lu and Ching-Yu Cheng and Xueling Sim and Dina Vojinovic and Huffman, {Jennifer E.} and Musani, {Solomon K.} and Changwei Li and Feitosa, {Mary F.} and Richard, {Melissa A.} and Raymond Noordam and Jenna Baker and Guanjie Chen and Hugues Aschard and Bartz, {Traci M.} and Jingzhong Ding and Rajkumar Dorajoo and Manning, {Alisa K.} and Tuomo Rankinen and Albert Smith and Tajuddin, {Salman M.} and Wei Zhao and Mariaelisa Graff and Maris Alver and Mathilde Boissel and Yanick Hagemeijer and Nolte, {Ilja M.} and Bram Prins and Said, {M. Abdullah} and {van der Most}, {Peter J.} and Zhao, {Jing Hua} and Marzyeh Amini and {de Vries}, {Paul S.} and Eppinga, {Ruben N.} and Harold Snieder and Oldehinkel, {Albertine J.} and Penninx, {Brenda W. J. H.} and {van der Harst}, Pim and Wang, {Ya Xing}",
year = "2019",
month = "4",
doi = "10.1038/s41588-019-0378-y",
language = "English",
volume = "51",
pages = "636--+",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

AU - COGENT-Kidney Consortium

AU - EPIC-InterAct Consortium

AU - Understanding Soc Sci Grp

AU - Lifelines Cohort

AU - Bentley, Amy R.

AU - Sung, Yun J.

AU - Brown, Michael R.

AU - Winkler, Thomas W.

AU - Kraja, Aldi T.

AU - Ntalla, Ioanna

AU - Schwander, Karen

AU - Chasman, Daniel

AU - Lim, Elise

AU - Deng, Xuan

AU - Guo, Xiuqing

AU - Liu, Jingmin

AU - Lu, Yingchang

AU - Cheng, Ching-Yu

AU - Sim, Xueling

AU - Vojinovic, Dina

AU - Huffman, Jennifer E.

AU - Musani, Solomon K.

AU - Li, Changwei

AU - Feitosa, Mary F.

AU - Richard, Melissa A.

AU - Noordam, Raymond

AU - Baker, Jenna

AU - Chen, Guanjie

AU - Aschard, Hugues

AU - Bartz, Traci M.

AU - Ding, Jingzhong

AU - Dorajoo, Rajkumar

AU - Manning, Alisa K.

AU - Rankinen, Tuomo

AU - Smith, Albert

AU - Tajuddin, Salman M.

AU - Zhao, Wei

AU - Graff, Mariaelisa

AU - Alver, Maris

AU - Boissel, Mathilde

AU - Hagemeijer, Yanick

AU - Nolte, Ilja M.

AU - Prins, Bram

AU - Said, M. Abdullah

AU - van der Most, Peter J.

AU - Zhao, Jing Hua

AU - Amini, Marzyeh

AU - de Vries, Paul S.

AU - Eppinga, Ruben N.

AU - Snieder, Harold

AU - Oldehinkel, Albertine J.

AU - Penninx, Brenda W. J. H.

AU - van der Harst, Pim

AU - Wang, Ya Xing

PY - 2019/4

Y1 - 2019/4

N2 - The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

AB - The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

KW - ENVIRONMENT INTERACTION

KW - GENOTYPE IMPUTATION

KW - NICOTINE METABOLISM

KW - RISK LOCI

KW - METAANALYSIS

KW - ARCHITECTURE

KW - CHOLESTEROL

KW - CIGARETTES

KW - VARIANTS

KW - SUSCEPTIBILITY

U2 - 10.1038/s41588-019-0378-y

DO - 10.1038/s41588-019-0378-y

M3 - Article

VL - 51

SP - 636-+

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 4

ER -

ID: 79730876