Publication
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Soc Sci Grp & Lifelines Cohort, Apr-2019, In : Nature Genetics. 51, 4, p. 636-+ 16 p.Research output: Contribution to journal › Article › Academic › peer-review

Documents
- Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Final publisher's version, 1.67 MB, PDF document
Links
- http://oro.open.ac.uk/68066/1/Bentley%20et%20al2019.pdf
Final author's version
DOI
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Original language | English |
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Pages (from-to) | 636-+ |
Number of pages | 16 |
Journal | Nature Genetics |
Volume | 51 |
Issue number | 4 |
Publication status | Published - Apr-2019 |
- ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, NICOTINE METABOLISM, RISK LOCI, METAANALYSIS, ARCHITECTURE, CHOLESTEROL, CIGARETTES, VARIANTS, SUSCEPTIBILITY
Keywords
ID: 79730876