Publication

MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

Du, L., Wang, L., Gan, J., Yao, Z., Lin, W., Li, J., Guo, Y., Chen, Y., Zhou, F., Jim Yeung, S-C., Coppes, R. P., Zhang, D. & Zhang, H., 20-Dec-2019, In : iScience . 22, p. 353-368 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Liang Du
  • Lu Wang
  • Jinfeng Gan
  • Zhimeng Yao
  • Wan Lin
  • Junkuo Li
  • Yi Guo
  • Yuping Chen
  • Fuyou Zhou
  • Sai-Ching Jim Yeung
  • Robert P Coppes
  • Dianzheng Zhang
  • Hao Zhang

Cancer cell stemness (CCS) plays critical roles in bothmalignancy maintenance andmetastasis, yet the underlying molecular mechanisms are far from complete. Although the importance of SOX2 in cancer development and CCS are well recognized, the role of MTA3 in these processes is unknown. In this study, we used esophageal squamous cell carcinoma (ESCC) as a model system to demonstrate that MTA3 can repress both CCS and metastasis in vitro and in vivo. Mechanistically, by forming a repressive complex with GATA3, MTA3 downregulates SOX2OT, subsequently suppresses the SOX2OT/SOX2 axis, and ultimately represses CCS and metastasis. More importantly, MTA3(low)/SOX2(high) is associated with poor prognosis and could serve as an independent prognostic factor. These findings altogether indicate that MTA3/SOX2OT/SOX2 axis plays an indispensable role in CCS. Therefore, this axis could be potentially used in cancer stratification and serves as a therapeutic target.

Original languageEnglish
Pages (from-to)353-368
Number of pages16
JournaliScience
Volume22
Publication statusPublished - 20-Dec-2019

    Keywords

  • LONG NONCODING RNA, CELL-PROLIFERATION, BREAST-CANCER, GENE MTA3, METASTASIS, EXPRESSION, CARCINOMA, SOX2, CONTRIBUTES, PROGRESSION

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