Publication

Modulation of the secretory pathway by amino-acid starvation

van Leeuwen, W., van der Krift, F. & Rabouille, C., 2-Jul-2018, In : Journal of Cell Biology. 217, 7, p. 2261-2271 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

van Leeuwen, W., van der Krift, F., & Rabouille, C. (2018). Modulation of the secretory pathway by amino-acid starvation. Journal of Cell Biology, 217(7), 2261-2271. https://doi.org/10.1083/jcb.201802003

Author

van Leeuwen, Wessel ; van der Krift, Felix ; Rabouille, Catherine. / Modulation of the secretory pathway by amino-acid starvation. In: Journal of Cell Biology. 2018 ; Vol. 217, No. 7. pp. 2261-2271.

Harvard

van Leeuwen, W, van der Krift, F & Rabouille, C 2018, 'Modulation of the secretory pathway by amino-acid starvation', Journal of Cell Biology, vol. 217, no. 7, pp. 2261-2271. https://doi.org/10.1083/jcb.201802003

Standard

Modulation of the secretory pathway by amino-acid starvation. / van Leeuwen, Wessel; van der Krift, Felix; Rabouille, Catherine.

In: Journal of Cell Biology, Vol. 217, No. 7, 02.07.2018, p. 2261-2271.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

van Leeuwen W, van der Krift F, Rabouille C. Modulation of the secretory pathway by amino-acid starvation. Journal of Cell Biology. 2018 Jul 2;217(7):2261-2271. https://doi.org/10.1083/jcb.201802003


BibTeX

@article{b9cbd3575fe041cf958de26b2adcdeff,
title = "Modulation of the secretory pathway by amino-acid starvation",
abstract = "As a major anabolic pathway, the secretory pathway needs to adapt to the demands of the surrounding environment and responds to different exogenous signals and stimuli. In this context, the transport in the early secretory pathway from the endoplasmic reticulum (ER) to the Golgi apparatus appears particularly regulated. For instance, protein export from the ER is critically stimulated by growth factors. Conversely, nutrient starvation also modulates functions of the early secretory pathway in multiple ways. In this review, we focus on amino-acid starvation and how the function of the early secretory pathway is redirected to fuel autophagy, how the ER exit sites are remodeled into novel cytoprotective stress assemblies, and how secretion is modulated in vivo in starving organisms. With the increasingly exciting knowledge on mechanistic target of rapamycin complex 1 (mTORC1), the major nutrient sensor, it is also a good moment to establish how the modulation of the secretory pathway by amino-acid restriction intersects with this major signaling hub.",
keywords = "ER-EXIT SITES, PRE-AUTOPHAGOSOMAL STRUCTURE, STRESS GRANULE FORMATION, TRANSITIONAL ER, COPII VESICLES, ENDOPLASMIC-RETICULUM, PHASE-SEPARATION, MTORC1 PATHWAY, PREAUTOPHAGOSOMAL STRUCTURE, NUTRIENT RESPONSE",
author = "{van Leeuwen}, Wessel and {van der Krift}, Felix and Catherine Rabouille",
year = "2018",
month = "7",
day = "2",
doi = "10.1083/jcb.201802003",
language = "English",
volume = "217",
pages = "2261--2271",
journal = "The Journal of Cell Biology",
issn = "0021-9525",
publisher = "ROCKEFELLER UNIV PRESS",
number = "7",

}

RIS

TY - JOUR

T1 - Modulation of the secretory pathway by amino-acid starvation

AU - van Leeuwen, Wessel

AU - van der Krift, Felix

AU - Rabouille, Catherine

PY - 2018/7/2

Y1 - 2018/7/2

N2 - As a major anabolic pathway, the secretory pathway needs to adapt to the demands of the surrounding environment and responds to different exogenous signals and stimuli. In this context, the transport in the early secretory pathway from the endoplasmic reticulum (ER) to the Golgi apparatus appears particularly regulated. For instance, protein export from the ER is critically stimulated by growth factors. Conversely, nutrient starvation also modulates functions of the early secretory pathway in multiple ways. In this review, we focus on amino-acid starvation and how the function of the early secretory pathway is redirected to fuel autophagy, how the ER exit sites are remodeled into novel cytoprotective stress assemblies, and how secretion is modulated in vivo in starving organisms. With the increasingly exciting knowledge on mechanistic target of rapamycin complex 1 (mTORC1), the major nutrient sensor, it is also a good moment to establish how the modulation of the secretory pathway by amino-acid restriction intersects with this major signaling hub.

AB - As a major anabolic pathway, the secretory pathway needs to adapt to the demands of the surrounding environment and responds to different exogenous signals and stimuli. In this context, the transport in the early secretory pathway from the endoplasmic reticulum (ER) to the Golgi apparatus appears particularly regulated. For instance, protein export from the ER is critically stimulated by growth factors. Conversely, nutrient starvation also modulates functions of the early secretory pathway in multiple ways. In this review, we focus on amino-acid starvation and how the function of the early secretory pathway is redirected to fuel autophagy, how the ER exit sites are remodeled into novel cytoprotective stress assemblies, and how secretion is modulated in vivo in starving organisms. With the increasingly exciting knowledge on mechanistic target of rapamycin complex 1 (mTORC1), the major nutrient sensor, it is also a good moment to establish how the modulation of the secretory pathway by amino-acid restriction intersects with this major signaling hub.

KW - ER-EXIT SITES

KW - PRE-AUTOPHAGOSOMAL STRUCTURE

KW - STRESS GRANULE FORMATION

KW - TRANSITIONAL ER

KW - COPII VESICLES

KW - ENDOPLASMIC-RETICULUM

KW - PHASE-SEPARATION

KW - MTORC1 PATHWAY

KW - PREAUTOPHAGOSOMAL STRUCTURE

KW - NUTRIENT RESPONSE

U2 - 10.1083/jcb.201802003

DO - 10.1083/jcb.201802003

M3 - Review article

VL - 217

SP - 2261

EP - 2271

JO - The Journal of Cell Biology

JF - The Journal of Cell Biology

SN - 0021-9525

IS - 7

ER -

ID: 75524691